A comparative study of serum uric acid, glucose, calcium and magnesium in pre-eclampsia and normal pregnancy

  • Arun Dhungana Kathmandu Medical college, Kathmandu, Nepal http://orcid.org/0000-0003-2083-649X
  • Aakriti Bharati Kathmandu Medical college, Kathmandu, Nepal
  • Rosina Manandhar Kathmandu Medical college, Kathmandu, Nepal
  • Chanda Karki Kathmandu Medical college, Kathmandu, Nepal
Keywords: Calcium, Glucose, Magnesium, Preclampsia, Pregnancy, Total protein, Uric acid

Abstract

Background: Preeclampsia is associated with liver function abnormalities and renal function impairment. The objective of this study is to compare serum uric acid, glucose, calcium and magnesium in pre-eclampsia with normal pregnancy.

Materials and Methods: Normal pregnant women and pre eclamptic women of age group 20-40 years were included. Serum magnesium, calcium, glucose, uric acid were analyzed.

Results: Mean serum magnesium level in preeclampsia (1.83 ± 0.21mg/dl) was lesser in comparison to normal pregnant women (2.03 ± 0.16 mg/dl). Serum calcium level was lower (8.10 ±0.56mg/dl) than control (9.59 ±0.62 mg/dl) with p<0.001. Uric acid, glucose and lactate dehydrogenase in preeclamptic women was significantly higher than that in normal pregnant women (6.14 ± 0.85 vs.4.01 ± 0.62, p=<0.001), (94.17± 18.65 vs.86.34 ± 10.19, p=0.033) and ( 466.80 ± 97.29 vs. 194.22 ± 39.76, p=<0.001) respectively.

Conclusion: There were significant changes in serum magnesium, uric acid, calcium, glucose, lactate dehydrogenase and total protein in pregnant women.

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Author Biographies

Arun Dhungana, Kathmandu Medical college, Kathmandu, Nepal
Biochemistry
Aakriti Bharati, Kathmandu Medical college, Kathmandu, Nepal
Obstetrics and Gynaecology
Rosina Manandhar, Kathmandu Medical college, Kathmandu, Nepal
Obstetrics and Gynaecology
Chanda Karki, Kathmandu Medical college, Kathmandu, Nepal
Obstetrics and Gynaecology
Published
2017-09-01
How to Cite
Dhungana, A., Bharati, A., Manandhar, R., & Karki, C. (2017). A comparative study of serum uric acid, glucose, calcium and magnesium in pre-eclampsia and normal pregnancy. Journal of Pathology of Nepal, 7(2), 1155-1161. https://doi.org/10.3126/jpn.v7i2.17995
Section
Original Articles