Tumor dedifferentiation: diagnostic and therapeutic implications

  • Abhimanyu Jha Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Keywords: Carcinoma, Dedifferentiation, Liposarcoma, Melanoma, Sarcoma,

Abstract

Some of the neoplasm especially malignant tumors are notorious in masquerading their cell of origin because of additional mutations which drives them to differentiate into unusual phenotype. This is implicated to a phenomenon of tumor dedifferentiation which can mislead into inappropriate categorization and therapy. Dedifferentiation is well recognized in sarcomas such as liposarcoma, chondrosarcoma and MPNST. However, it can also develop in carcinomas, melanomas and lymphomas at initial diagnosis, following therapy or at recurrence.  The phenomenon has been reported in both primary tumors as well as at metastatic foci. A correct and early pathological identification of this phenomenon might profoundly help in guiding appropriate therapy. Clinical and radiological findings, immunohistochemistry and genetic analysis are often required for correct lineage identification of these tumors.

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Author Biography

Abhimanyu Jha, Tribhuvan University Teaching Hospital, Maharajgunj, Kathmandu, Nepal
Pathology
Published
2017-09-01
How to Cite
Jha, A. (2017). Tumor dedifferentiation: diagnostic and therapeutic implications. Journal of Pathology of Nepal, 7(2), 1202-1211. https://doi.org/10.3126/jpn.v7i2.18021
Section
Review Articles