Langerhans cell histiocytosis; an institutional study

Authors

DOI:

https://doi.org/10.3126/jpn.v7i2.18032

Keywords:

Bone, Childhood, Histiocytosis, Langerhans cell

Abstract

Background: Langerhans cell histiocytosis is a complex rare disease of the dendritic cell system.The disease can occur at any age, with a peak at 5-10 years. Here, we present the spectrum of this uncommon disease with different sites of involvement and its histopathological differential diagnosis. 

Material and Methods:  Study included 24 cases of Langerhans cell histiocytosis out of approximately 50,000 biopsies received in the department.

Results: The male to female ratio was 1.6:1 with mean age of 12 years. Commonest site of involvement was skin 37.5%, followed by bone 33.4%. Lymph nodes 20.9%, bone marrow 4.1% and thyroid 4.1% involvement was seen. Among the 9 cases of bone involvement, commonest site was humerus (3 cases), sternum (2 cases) and one case each in frontal bone, fibula, temporal bone and rib.

Conclusion: Langerhans cell histiocytosis should be considered in the differential diagnosis of histiocytic lesions involving various organs, especially in childhood. 

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Author Biographies

Shovana Karki, Tribhuvan Universtiy Teaching Hospital

Pathology

Aasia Rajbhandari, Tribhuvan University Teaching Hospital

Resident

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Published

2017-09-01

How to Cite

Karki, S., & Rajbhandari, A. (2017). Langerhans cell histiocytosis; an institutional study. Journal of Pathology of Nepal, 7(2), 1192–1195. https://doi.org/10.3126/jpn.v7i2.18032

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Original Articles

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