Diagnostic utility of trophoblastic cell surface antigen 2 immunohistochemical expression in papillary thyroid carcinoma

Authors

  • Hafez H Nesreen National Cancer Institute, Cairo University http://orcid.org/0000-0001-6608-3230
  • Shalaby Z Manal National Cancer Institute, Cairo University
  • Ahmed M Mohamed National Cancer Institute, Cairo University

DOI:

https://doi.org/10.3126/jpn.v8i1.19442

Keywords:

Immunostain, Papillary carcinoma, TROP-2, Trophoblastic

Abstract

Background: Although nuclear criteria are considered to be characteristic for papillary thyroid carcinoma, some cases do raise controversy as being papillary thyroid carcinoma or non-papillary thyroid carcinoma due to unclear diagnostic nuclear features. Immunohistochemical markers can help in identifying PTC. Trophoblastic cell surface antigen 2 (TROP-2) is a novel marker that is recently applied on thyroid. The aim of this study was to evaluate TROP-2 expression and diagnostic utility in PTC compared to other thyroid nodules with follicular pattern on tissue specimens and cell block sections. 

Materials and Methods: This retrospective study was carried out at National Cancer Institute, Cairo University between January 2010 and January 2015. Immunohistochemical evaluation of TROP-2 was applied on archival 110 surgically excised and 66 cytological cell blocks of PTC and other follicular thyroid nodules. Membranous staining, with or without cytoplasm, was considered positive.

Results: Among excised specimens, 85.1% of PTC demonstrated TROP-2 staining. The majority revealed diffuse staining. No significant staining difference was reported between studied classic and non classic variants. TROP-2 sensitivity and were 85.1% and 94.4%. Among cytological materials, all PTC were positive except two (false negative) and only two follicular adenomas were positive (false positive). TROP-2 sensitivity and specificity were 93.8% and 94.1%. None of nodular hyperplasia or adjacent normal thyroid tissues showed TROP-2 immunoreactivity either on histopathological or cytological sections.

Conclusion: TROP-2 positivity was significantly higher in PTC compared to all other studied non PTC lesion in both surgical pathology specimens and cytological materials. No reported significant staining difference among studied PTC variant.

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Author Biographies

Hafez H Nesreen, National Cancer Institute, Cairo University

Pathology

Shalaby Z Manal, National Cancer Institute, Cairo University

Medicine

Ahmed M Mohamed, National Cancer Institute, Cairo University

Reproductive Health and Family Planning Research

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Published

2018-04-03

How to Cite

Nesreen, H. H., Manal, S. Z., & Mohamed, A. M. (2018). Diagnostic utility of trophoblastic cell surface antigen 2 immunohistochemical expression in papillary thyroid carcinoma. Journal of Pathology of Nepal, 8(1), 1235–1243. https://doi.org/10.3126/jpn.v8i1.19442

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Original Articles