Correlation between histopathological and endoscopic findings of non-malignant gastrointestinal lesions: an experience of a tertiary care teaching hospital from Northern India

  • Manpreet Kaur Sri Guru Ram Das Institute of Medical Sciences and Research
  • Tejinder Singh Bhasin Sri Guru Ram Das Institute of Medical Sciences and Research
  • Mridu Manjari Sri Guru Ram Das Institute of Medical Sciences and Research
  • Rahul Mannan Sri Guru Ram Das Institute of Medical Sciences and Research
  • Sonam Sharma Sri Guru Ram Das Institute of Medical Sciences and Research http://orcid.org/0000-0001-9856-9542
  • Gurupriya Anand Sri Guru Ram Das Institute of Medical Sciences and Research
Keywords: Endoscopy, Gastrointestinal biopsies, Histopathology, India, Non-malignant

Abstract

Background: Gastrointestinal tract endoscopy along with biopsy is an established procedure for investigating a wide range of gastrointestinal conditions especially inflammatory and malignant diseases. The aim was to study and categorizing the morphological lesions of non-malignant origin at various sites of gastrointestinal tract and to compare with its endoscopic findings.

Materials and Methods: This study was conducted on 280 benign GI biopsies received in the Department of Pathology of Sri Guru Ram Das Institute of Medical Sciences and Research, Amritsar, Punjab, India.

Results: Maximum cases (39%) were observed in the age group of 41-60 years. Male patients outnumbered the females (male to female ratio was 1.4:1). There were total 33 esophageal biopsies amongst which the most common lesion was non-specific esophagitis with least common being Barrett’s esophagus. Correlating the results of endoscopic and histopathological features of acute and chronic gastritis a positive predictive value of 80% with sensitivity of 44.4% was seen. Total 83 duodenal biopsies were analyzed with non-specific duodenitis being the most commonly diagnosed lesion followed by celiac disease. Correlation of endoscopic and histopathological findings in celiac disease revealed a sensitivity of 50% and positive predictive value of 42.86%. In both sigmoid colon and rectum, non-specific colitis was the commonest diagnosis followed by ulcerative colitis. Endoscopic findings were correlated with the histopathological features in ulcerative colitis, revealing a sensitivity of 57.14% along with the positive predictive value of 80%.  

Conclusion: Histopathology remains the gold standard for diagnosing a case along with endoscopic findings and endoscopic findings alone cannot make the final diagnosis.

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Author Biographies

Manpreet Kaur, Sri Guru Ram Das Institute of Medical Sciences and Research
Pathology
Tejinder Singh Bhasin, Sri Guru Ram Das Institute of Medical Sciences and Research
Pathology
Mridu Manjari, Sri Guru Ram Das Institute of Medical Sciences and Research
Pathology
Rahul Mannan, Sri Guru Ram Das Institute of Medical Sciences and Research
Pathology
Sonam Sharma, Sri Guru Ram Das Institute of Medical Sciences and Research
Pathology
Gurupriya Anand, Sri Guru Ram Das Institute of Medical Sciences and Research
Pathology
Published
2018-04-03
How to Cite
Kaur, M., Bhasin, T., Manjari, M., Mannan, R., Sharma, S., & Anand, G. (2018). Correlation between histopathological and endoscopic findings of non-malignant gastrointestinal lesions: an experience of a tertiary care teaching hospital from Northern India. Journal of Pathology of Nepal, 8(1), 1289-1296. https://doi.org/10.3126/jpn.v8i1.19456
Section
Original Articles