Colloid cyst of third ventricle: Histopathological and ultrastructural study

Authors

  • Prasanna Karki Neurosurgery Division, Nepal Mediciti Hospital, Kathmandu, Nepal
  • Sameer Chhetri Aryal Nepal Mediciti Hospital, Lalitpur, Nepal
  • Gopi Aryal Nepal Mediciti Hospital, Lalitpur, Nepal http://orcid.org/0000-0002-8566-2593
  • Rajesh Panth Nepal Mediciti Hospital, Lalitpur, Nepal
  • Manoj Bohara Nepal Mediciti Hospital, Kathmandu, Nepal
  • Sumit Joshi Nepal Mediciti Hospital, Lalitpur, Nepal
  • Prakash Paudel Nepal Mediciti Hospital, Lalitpur, Nepal
  • Damber Bikram Shah Nepal Mediciti Hospital, Lalitpur, Nepal
  • Gopal Raman Sharma Nepal Mediciti Hospital, Lalitpur, Nepal

DOI:

https://doi.org/10.3126/jpn.v9i2.24882

Keywords:

Colloid cyst, Hydocephalus, Third ventricle

Abstract

Cysts occupying the third ventricle are rare lesions and may appear as an unusual cause of hydrocephalic crisis. A 40-year old woman with headache and one episode of fainting attack was diagnosed with a cystic lesion in the third ventricle after brain MRI study. She was operated with the pre-operative diagnosis of a colloid cyst. A yellowish, thick and mucoid cyst was observed intra-operatively. The total removal of the cyst was done along with the cyst wall. On histopathological evaluation, the cyst wall was lined by ciliated cuboidal to pseudostratified columnar epithelium resting on an eosinophilic basement membrane. The ultrastructural study showed the characteristic 9+2 pattern of cilia. Immunohistochemistry showed positive staining for epithelial membrane antigen (EMA), cytokeratin (CK), and negative staining for Glial fibrillary acidic protein (GFAP). Histopathological and ultrastructural findings confirm the diagnosis of a colloid cyst of third ventricles favoring the endodermal origin of the cyst.

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Author Biographies

Prasanna Karki, Neurosurgery Division, Nepal Mediciti Hospital, Kathmandu, Nepal

Department of Neuroscience

Sameer Chhetri Aryal, Nepal Mediciti Hospital, Lalitpur, Nepal

Department of Laboratory Medicine & Pathology

Gopi Aryal, Nepal Mediciti Hospital, Lalitpur, Nepal

Professor, Department of Laboratory Medicine & Pathology

Rajesh Panth, Nepal Mediciti Hospital, Lalitpur, Nepal

Department of Laboratory Medicine & Pathology

Manoj Bohara, Nepal Mediciti Hospital, Kathmandu, Nepal

Department of Neurosciences, Neurosurgery division

Sumit Joshi, Nepal Mediciti Hospital, Lalitpur, Nepal

Department of Neurosciences, Neurosurgery division

Prakash Paudel, Nepal Mediciti Hospital, Lalitpur, Nepal

Department of Neurosciences, Neurosurgery division

Damber Bikram Shah, Nepal Mediciti Hospital, Lalitpur, Nepal

Department of Neurosciences, Neurosurgery division

Gopal Raman Sharma, Nepal Mediciti Hospital, Lalitpur, Nepal

Department of Neurosciences, Neurosurgery division

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Published

2019-09-29

How to Cite

Karki, P., Aryal, S. C., Aryal, G., Panth, R., Bohara, M., Joshi, S., Paudel, P., Shah, D. B., & Sharma, G. R. (2019). Colloid cyst of third ventricle: Histopathological and ultrastructural study. Journal of Pathology of Nepal, 9(2), 1590–1594. https://doi.org/10.3126/jpn.v9i2.24882

Issue

Section

Case Reports