Assessment of plasma insulin, c-peptide, and blood pressure parameters of type 1 and type 2 diabetes mellitus and diabetic complications

Authors

  • Friday K. Iweka Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • Godwin R.A. Okogun Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • Ebenezer O. Dic-Ijiewere Ambrose Alli University, Ekpoma, Edo State, Nigeria http://orcid.org/0000-0001-6864-8979
  • Lawrence F. Dada Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • Iredia K. Akhuemokhan Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria
  • Basil N. Obodo Ambrose Alli University, Ekpoma, Edo State, Nigeria
  • Omotejohwo A. Onoyovwi Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria
  • Omoruyi Egherevba Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria

DOI:

https://doi.org/10.3126/jpn.v10i1.27324

Keywords:

Coronary Heart Disease, Diabetes Mellitus, Nephropathy, Neuropathy

Abstract

Background: Regardless of the type of diabetes mellitus, there is always a Beta-cell dysfunction leading to absolute insulin deficiency in type 1 diabetes mellitus or associated with insulin resistance in case of type 2 diabetes mellitus.

Materials and Methods: A total of 267 subjects consisting of 164 diabetic patients and 103 non-diabetic apparently healthy individuals were analysed. The plasma insulin and c-peptides levels were determined using enzyme link immunosorbent assay, while plasma glucose level was determined using standard spectrophotometric method.

Results: The biochemical results showed that the mean plasma glucose of Type 1 diabetes (213.65±20.35) and Type 2 diabetes (218.78+7.85) were significantly (P<0.05) higher than that of non-diabetic control (81.88±17.22) mg/dl; the mean plasma glucose and the systolic reading of the Diabetes Mellitus with Nephropathy, hypertension, coronary artery disease, neuropathy, and retinopathy patients were significantly (p<0.05) higher than the control subjects. Among diabetic hypertensive patients mean insulin and c-peptide levels were significantly (p<0.05) lower, while the mean insulin level was insignificantly (p>0.05) lower in diabetic patients with neuropathy or coronary artery disease. No significant (p>0.05) differences was observed in the mean plasma c-peptide level, and diastolic reading of diabetic patient with neuropathy. There were no significant (p>0.05) differences in the mean plasma c-peptide level, systolic and diastolic readings of Diabetic patients with coronary heart disease or retinopathy.

Conclusion: There were significant differences in the blood pressure parameters in both the diabetes mellitus and diabetic complications in this study.

 

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Author Biographies

Friday K. Iweka, Ambrose Alli University, Ekpoma, Edo State, Nigeria

Associate Professor, Department of Medical Laboratory Science

Godwin R.A. Okogun, Ambrose Alli University, Ekpoma, Edo State, Nigeria

Department of Medical Laboratory Science

Ebenezer O. Dic-Ijiewere, Ambrose Alli University, Ekpoma, Edo State, Nigeria

Department of Clinical Pathology

Lawrence F. Dada, Ambrose Alli University, Ekpoma, Edo State, Nigeria

Department of Medical Laboratory Science

Iredia K. Akhuemokhan, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria

Department of Internal Medicine

Basil N. Obodo, Ambrose Alli University, Ekpoma, Edo State, Nigeria

Department of Medical Laboratory Science

Omotejohwo A. Onoyovwi, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria

Department of Chemical Pathology

Omoruyi Egherevba, Irrua Specialist Teaching Hospital, Irrua, Edo State, Nigeria

Department of Chemical Pathology

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Published

2020-05-12

How to Cite

Iweka, F. K., Okogun, G. R., Dic-Ijiewere, E. O., Dada, L. F., Akhuemokhan, I. K., Obodo, B. N., Onoyovwi, O. A., & Egherevba, O. (2020). Assessment of plasma insulin, c-peptide, and blood pressure parameters of type 1 and type 2 diabetes mellitus and diabetic complications. Journal of Pathology of Nepal, 10(1), 1635–1638. https://doi.org/10.3126/jpn.v10i1.27324

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