A study of correlation of plasma fibrinogen levels with glycemic status in type 2 Diabetes Mellitus patients

  • Pravinkumar V Ghongade Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha Maharashtra, India
  • Manisha Anantrao Atram Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha Maharashtra, India http://orcid.org/0000-0002-7970-4216
  • Vitaladevuni B Shivkumar Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha Maharashtra, India
Keywords: Complications; Glycated hemoglobin; Plasma fibrinogen; Type 2 diabetes mellitus

Abstract

Background: Plasma fibrinogen is an indicator of inflammation and endothelial dysfunction has been described as an independent risk factor for cardiovascular morbidity in type 2 Diabetes mellitus patients. Poor glycemic control has been reported to be associated with hyperfibrinogenemia and its complications. This study was aimed to find a correlation of mean fibrinogen level with glycemic control in complicated and uncomplicated cases of Type 2 Diabetes mellitus.

Materials and methods: One hundred eight known cases of Type 2 Diabetes mellitus aged ≥ 30 were included in our study of which 39 cases were uncomplicated and 69 cases were complicated Diabetes mellitus. Hundred of non-diabetic age and sex-matched controls were analyzed. Blood samples were collected in Ethylenediaminetetraacetic acid and citrate bulb for estimation of HbA1c and plasma fibrinogen level respectively.

Results: Mean fibrinogen level in complicated Type 2 Diabetes mellitus was high 450.43 ±108.51 mg/dl as compared to uncomplicated cases 372.30±123.78 mg/dl (p=0.0001). Mean HbA1c in total Diabetes mellitus cases was 8.02±1.88 mg/dl with a range of 5.50-14.50 mg/dl. A positive correlation was found between HbA1c and mean fibrinogen level (r=0.782, p= 0.001) in type 2 Diabetes mellitus. Duration of diabetes in years showed a significant correlation with mean fibrinogen levels (r=0.295, p=0.002).

Conclusions: Plasma fibrinogen level was significantly associated with glycemic control (HbA1c) and duration of Diabetes mellitus in years. Thus, lowering plasma fibrinogen levels could be an important approach to the prevention of cardiovascular complications in diabetics.

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Author Biographies

Pravinkumar V Ghongade, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha Maharashtra, India

Assistant Professor, Department of Pathology  

Manisha Anantrao Atram, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha Maharashtra, India

Associate Professor, Department of Pathology 

Vitaladevuni B Shivkumar, Mahatma Gandhi Institute of Medical Sciences, Sewagram, Wardha Maharashtra, India

Professor, Department of Patholgy

Published
2020-09-30
How to Cite
Ghongade, P., Atram, M., & Shivkumar, V. (2020). A study of correlation of plasma fibrinogen levels with glycemic status in type 2 Diabetes Mellitus patients. Journal of Pathology of Nepal, 10(2), 1746-1750. https://doi.org/10.3126/jpn.v10i2.28706
Section
Original Articles