Mixed adenoneuroendocrine carcinoma of proximal stomach; a rare but sinister pathology

  • Deepshikha Gaire Tribhuvan University Teaching Hospital https://orcid.org/0000-0002-2512-3344
  • Daisy Maharjan Tribhuvan University Teaching hospital, Kathmandu, Nepal
  • Nisha Sharma Tribhuvan University Teaching hospital, Kathmandu, Nepal
Keywords: Gastric carcinoma; Immunohistochemistry; MANEC

Abstract

Mixed adeno-neuroendocrine carcinoma is a rare tumor of the gastrointestinal tract comprising of both epithelial and neuroendocrine components, each representing at least 30% of the tumor. Diagnosis is based on clinical evaluation, radiological findings, histopathological features in conjunction with immunostaining with specific neuroendocrine markers such as chromogranin, synaptophysin, CD56, and markers of epithelial differentiation such as cytokeratin, CDX2, and carcinoembryonic antigen. A 50-year-old female presented with a history of dysphagia, chest pain, anorexia, and significant weight loss with normal physical findings and baseline investigations. Upper Gastrointestinal endoscopy showed growth at the gastroesophageal junction involving cardia of the stomach. Histopathological examination of the resected mass showed both adenocarcinoma and neuroendocrine carcinomatous components each involving more than 30% of total mass examined. Identifying adenocarcinoma component admixed with a high-grade neuroendocrine component is significant as the prognosis and survival of patients differ from pure adenocarcinoma.

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Author Biographies

Deepshikha Gaire, Tribhuvan University Teaching Hospital

Resident, Department of Pathology

Daisy Maharjan, Tribhuvan University Teaching hospital, Kathmandu, Nepal

Department of Pathology

Nisha Sharma, Tribhuvan University Teaching hospital, Kathmandu, Nepal

Department of Pathology

Published
2020-09-30
How to Cite
Gaire, D., Maharjan, D., & Sharma, N. (2020). Mixed adenoneuroendocrine carcinoma of proximal stomach; a rare but sinister pathology. Journal of Pathology of Nepal, 10(2), 1772-1775. https://doi.org/10.3126/jpn.v10i2.29050
Section
Case Reports