Histopathological findings on endometrial biopsy in a tertiary care center of Nepal: a retrospective cross-sectional study

Authors

  • Amar Narayan Shrestha Department of Pathology, Shree Birendra Hospital, Nepal https://orcid.org/0000-0003-4300-4223
  • Barun Babu Aryal BP Smriti Hospital, Kathmandu, Nepal
  • Anurag Adhikari Nepal Korea Friendship Hospital, Bhaktapur, Nepal
  • Ayusha Poudel Nepal Korea Friendship Hospital, Bhaktapur, Nepal
  • Ramhari Rouniyar BP Koirala Institute of Health Sciences, Nepal
  • Bidur Khatiwada Nepal Tuberculosis Control Center, Bhaktapur, Nepal

DOI:

https://doi.org/10.3126/jpn.v12i1.38595

Keywords:

Abnormal uterine bleeding; Endometrial biopsy; Endometrial hyperplasia

Abstract

Introduction: Abnormal uterine bleeding is the most common presentation in endometrial pathology and endometrial biopsy is the investigation of choice. This study aimed to describe the histological findings of patients who underwent endometrial biopsy to estimate the most common endometrial diseases in Nepali women.

Materials and methods: This retrospective cross-sectional study was conducted using hospital records, and included females who underwent endometrial biopsy at a tertiary level hospital from 1 April 2018 to 31 March 2020. Histopathological findings were categorized into eight groups, and patients were divided into three age groups to obtain the relative occurrence of each type of disease at different ages

Results:342 female patients were included in the study, among which 97 were pregnancy-related and 245 were non-pregnancy-related. The mean age of the patients was 41.63 years (± 11.45 years). In 28 cases (8.2%) of the 342 total cases, the endometrial biopsy sample was deemed inadequate. Among the non-pregnancy-related cases, normal physiological changes were the most common reported finding (n=93, 38.0%), followed by abnormal physiologic changes (n=68, 27.8%). Premalignant conditions (n=15, 6.1%) and malignancy (n=5, 2.0%) were less common.

Conclusions: Normal physiological changes and disordered proliferative endometrium are the most common findings in an endometrial biopsy. Endometrial hyperplasia and malignancy are less common, and usually found in women more than 40 years in age.

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Author Biographies

Amar Narayan Shrestha, Department of Pathology, Shree Birendra Hospital, Nepal

Department of Pathology

Barun Babu Aryal, BP Smriti Hospital, Kathmandu, Nepal

Medical officer

Anurag Adhikari, Nepal Korea Friendship Hospital, Bhaktapur, Nepal

Medical officer

Ayusha Poudel, Nepal Korea Friendship Hospital, Bhaktapur, Nepal

Medical officer

Ramhari Rouniyar, BP Koirala Institute of Health Sciences, Nepal

Medical officer

Bidur Khatiwada, Nepal Tuberculosis Control Center, Bhaktapur, Nepal

Medical officer

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Published

2022-03-31

How to Cite

Shrestha, A. N., Aryal, B. B., Adhikari, A., Poudel, A., Rouniyar, R., & Khatiwada, B. (2022). Histopathological findings on endometrial biopsy in a tertiary care center of Nepal: a retrospective cross-sectional study. Journal of Pathology of Nepal, 12(1), 1938–1942. https://doi.org/10.3126/jpn.v12i1.38595

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Original Articles