Role of platelet indices in pre-eclampsia: a case-control study at teaching hospital, Nepal

Authors

  • Prabesh Choudhary Nobel Medical college and teaching hospital https://orcid.org/0000-0001-7431-5820
  • Narendra Pandit Nobel Medical College, Biratnagar, Nepal
  • Niraj Nepal Nobel Medical College, Biratnagar, Nepal
  • M Yadav Nobel Medical College, Biratnagar, Nepal

DOI:

https://doi.org/10.3126/jpn.v13i2.58322

Keywords:

Mean platelet volume, Platelet count, Preeclampsia

Abstract

Background: Preeclampsia is one of the major health-related ailments causing increased maternal morbidity and mortality, and complicates up to 10% of pregnancies. The study aims to find out the utility of platelet indices for early prediction of preeclampsia.

Materials and Methods: It was a prospective case-control study that included a total of 84 patients (42 in the study group with preeclampsia and 42 controls with normal blood pressure) during a one-year study period. Fresh blood samples (2 ml) were collected for the platelet indices - platelet count (PC), plateletcrit (PCT), mean platelet volume (MPV), and platelet distribution width (PDW) – and were analyzed by fully automated cell counter by impedance method, and compared between the two groups.

Results: Both groups were comparable in terms of age, parity, gestational period, and body mass index. The PC and MPV showed a significant difference; (1.98±0.7 vs. 2.42±0.8; p= 0.01) and (12.44±0.6 vs.10.0±0.48; p= 0.03) between the two groups respectively.  However, the difference between the two groups was not statistically significant for PCT and PDW.

Conclusions: The low platelet count and an increased mean platelet volume were significant in patients with preeclampsia compared to the control group. It could be a marker for early diagnosis of preeclampsia in pregnancy.

Downloads

Download data is not yet available.
Abstract
178
PDF
69

Author Biographies

Prabesh Choudhary, Nobel Medical college and teaching hospital

Associate Professor, Department of Pathology

Narendra Pandit, Nobel Medical College, Biratnagar, Nepal

Department of Pathology

Niraj Nepal, Nobel Medical College, Biratnagar, Nepal

Department of Pathology

M Yadav, Nobel Medical College, Biratnagar, Nepal

Department of Pathology

Downloads

Published

2023-12-31

How to Cite

Choudhary, P. ., Pandit, N. ., Nepal, N. ., & Yadav, M. (2023). Role of platelet indices in pre-eclampsia: a case-control study at teaching hospital, Nepal. Journal of Pathology of Nepal, 13(2), 2043–2045. https://doi.org/10.3126/jpn.v13i2.58322

Issue

Section

Original Articles

Similar Articles

1 2 3 > >> 

You may also start an advanced similarity search for this article.