Correlation of Small Dense LDL Cholesterol and Apolipoprotein B with LDL Cholesterol and its Clinical Significance in Overweight, Type 2 Diabetes Mellitus and Coronary Artery Disease

Authors

  • Arabinda Mohan Bhattarai Assistant Prof, Department of Biochemistry, NAIHS
  • HS Batra Department of Biochemistry, AFMC, Pune-40
  • Suchit Bandyopadhyay Command Hospital, Eastern Command
  • Pratibha Misra National Center for Cell Science, University of Pune
  • Manushri Sharma Department of Biochemistry, LHMC, New Delhi
  • Deeprika Agarwal Department of Biochemistry, AFMC, Pune-40

DOI:

https://doi.org/10.3126/mjsbh.v14i2.14375

Keywords:

small dense LDL, Apo B, CAD, type 2 diabetes.

Abstract

Introduction: Atherosclerotic Coronary Artery Disease (CAD) is fundamentally related to disorders of lipid metabolism. Health problems like obesity, glucose intolerance and metabolic syndrome increase atherosclerotic CAD risk.  A fraction of Low density lipoprotein cholesterol (LDL) is called small dense low density lipoprotein cholesterol (sdLDL). These particles are more atherogenic because they are taken up more easily by arterial wall, readily oxidized and not easily cleared from plasma. Every LDL particle contain an Apo B molecule.

Methods: In this cross sectional study we recruited 100 known cases each of CAD, type 2 diabetes, overweight and 100 age and sex matched healthy controls. We took a detailed case summary along with anthropometric measurements. We measured sdLDL by heparin magnesium precipitation method followed by direct estimation of the LDL in the supernatant.

Result: Linear regressive analysis showed positive correlation between sdLDL and Apolipoprotein B (Apo B) with LDL cholesterol (r=0.61, p=0.004), (r=0.754, p=0.0034) respectively. Multiple Comparisons after Kruskalwallis test of sdLDL and Apo B levels of  type 2 diabetes, CAD and overweight with controls were significant (p<0.001).

Conclusion: Our findings suggest that the estimation of sdLDL and Apo B provide a complimentary benefit in assessment of cases with CAD, type 2 diabetes and overweight.

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Author Biography

Arabinda Mohan Bhattarai, Assistant Prof, Department of Biochemistry, NAIHS

Captain at Nepal Army Medical Corpse

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Published

2016-05-13

How to Cite

Bhattarai, A. M., Batra, H., Bandyopadhyay, S., Misra, P., Sharma, M., & Agarwal, D. (2016). Correlation of Small Dense LDL Cholesterol and Apolipoprotein B with LDL Cholesterol and its Clinical Significance in Overweight, Type 2 Diabetes Mellitus and Coronary Artery Disease. Medical Journal of Shree Birendra Hospital, 14(2), 36–40. https://doi.org/10.3126/mjsbh.v14i2.14375

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Original Articles