Spectrum of cytological patterns in cervical PAP smears in a tertiary care center of Western region of Nepal

  • Pragya Gautam Ghimire Nepalgunj Medical College, Banke, Nepal
  • Durga BC Rawat Nepalgunj Medical College, Banke, Nepal
  • Kavita Sinha Nepalgunj Medical College, Banke, Nepal
  • Kamar Jahan Nepalgunj Medical College, Banke, Nepal
  • Richa Shrestha Nepalgunj Medical College, Banke, Nepal
Keywords: cancer, cervical, Pap, screening

Abstract

Introduction: Cervical cancer is a common health problem in Nepal. There is paucity of data regarding the spectrum of findings in cervical Pap in western Nepal. This study was aimed to study the cytological patterns in cervical Pap smears in patients in a tertiary hospital of Nepal.

Methods: This is a prospective, cross sectional, hospital based study. Clinical features of patients who had presented with Pap smear was noted in a structured proforma. Pap smears were studied by a senior pathologist and reported based on revised Bethesda system (2014).

Results: Most of the cases belonged to 31-40 years 399 (42.8%). Unsatisfactory/ inadequate sample was present in 133(14.05%) with obscuration due to inflammatory exudate being most common cause. Negative for intraepithelial lesion or malignancy rate was noted in 798 (85.54%) with 477(51.2%) being normal findings. Epithelial cell abnormalities were noted in 116 (14.5 %) smears. Low-grade squamous intraepithelial lesion constituted 321(34.5%), High grade squamous intraepithelial lesion 273(29.3 %) and Atypical squamous cells of undetermined significance 153(16.4%) of epithelial cell abnormalities. Squamous cell carcinoma was present in 9(1%) of all reviewed smears. There was no statistical significance between the age and abnormalities of Pap smear (p=0.9).

Conclusions: Pap smear is pivotal in cervical cancer screening in developing countries. It also identifies various inflammatory, infective, benign and malignant pathologies at the earliest thereby decreasing the morbidity and mortality.

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Author Biographies

Pragya Gautam Ghimire, Nepalgunj Medical College, Banke, Nepal

Assistant Professor, Department of Pathology,

Durga BC Rawat, Nepalgunj Medical College, Banke, Nepal

Lecturer, Department of Obstetrics and Gynaecology

Kavita Sinha, Nepalgunj Medical College, Banke, Nepal

Assistant Professor, Department of Obstetrics and Gynaecology

Kamar Jahan, Nepalgunj Medical College, Banke, Nepal

Lecturer, Department of Obstetrics and Gynaecology

Richa Shrestha, Nepalgunj Medical College, Banke, Nepal

Lecturer, Department of Pathology

Published
2019-05-17
How to Cite
Ghimire, P., Rawat, D., Sinha, K., Jahan, K., & Shrestha, R. (2019). Spectrum of cytological patterns in cervical PAP smears in a tertiary care center of Western region of Nepal. Nepal Journal of Medical Sciences, 4(1), 2-8. https://doi.org/10.3126/njms.v4i1.24118
Section
Original Articles