Sickle cell disease in Western Nepal

  • Rajan Pande Bheri Provincial Hospital, Bheri Zone, Province no-5, Nepal
  • Pragya Gautam Ghimire Nepalgunj Medical College and Teaching Hospital, Bheri Zone, Province no-5, Nepal
  • Priyankar Bahadur Chand Sickle Cell Nepal, Kailali, Seti Zone, Province no-7, Nepal
  • Sharmila Gupta Nepalgunj Medical College and Teaching Hospital, Bheri Zone, Province no-5, Nepal
Keywords: foetal haemoglobin, haemoglobinopathy, Nepal, sickle cell disease

Abstract

Introduction: Since 2003, only few cases of sickle cell disease have officially been reported in Nepalese medical journals, and all reported patients belong to the Tharu ethnic group of Nepal. This is the first study that details sickle cell disease and carrier in 1250 individuals in western Nepal.

Methods: This is a retrospective review of the patients and carriers of sickle cell disease diagnosed by either a positive haemoglobin electrophoresis report or a positive high performance liquid chromatography (HPLC) report. Analysis was done using SPSS 20.

Results: Out of the 1250 individuals, 51.4% were females. 601 (48.08%) were patients with a form of sickle cell disease, the mean age was 24.5  12 yrs years. Most patients came from Bardiya district. Most common symptoms were related to joint pain. The patients and carriers of sickle cell disease were mostly from Tharu ethnic group (97.7%).

Conclusion: These data suggest that sickle cell disease and other haemoglobinopathies are more prevalent than previously reported among members of the Tharu ethnic group and other residents of western Nepal. More research is imperative to assess the burden of the sickle cell disease and other haemoglobinopathies in Nepal.

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Author Biographies

Rajan Pande, Bheri Provincial Hospital, Bheri Zone, Province no-5, Nepal

Chief consultant physician and Head of Department of Internal Medicine

Pragya Gautam Ghimire, Nepalgunj Medical College and Teaching Hospital, Bheri Zone, Province no-5, Nepal

Assistant Professor, Department of Pathology

Priyankar Bahadur Chand, Sickle Cell Nepal, Kailali, Seti Zone, Province no-7, Nepal

Cofounder

Sharmila Gupta, Nepalgunj Medical College and Teaching Hospital, Bheri Zone, Province no-5, Nepal

Lecturer, Department of Pathology

Published
2019-05-17
How to Cite
Pande, R., Ghimire, P., Chand, P., & Gupta, S. (2019). Sickle cell disease in Western Nepal. Nepal Journal of Medical Sciences, 4(1), 15-19. https://doi.org/10.3126/njms.v4i1.24121
Section
Clinical Audit