Noninvasive diagnosis of Helicobacter pylori among patients with dyspepsia
Keywords:Dyspepsia, Gastritis, Helicobacter pylori, Noninvasive tests
Introduction: Helicobacter pylori (H. pylori) infection is a common disease with disparity in geography, age, race and socioeconomic status. Present study aims to assess the accuracy of noninvasive diagnostic tests.
Methods: This is a hospital based cross sectional, observational study of 100 dyspeptic patients during November 2017- June 2018. Profile of dyspeptic patients were recorded in a proforma and accuracy of serology and stool antigen test for H. pylori was compared with histology detection in gastric biopsies.
Results: Mean age of patients was 39.5±13.7 years with almost equal gender distribution. Prevalence of H. pylori was 56% with dyspeptic symptoms in gastric biopsies. Significant association of the infection was seen in patients with a longer duration of dyspepsia, pangastritis on endoscopy and chronic gastritis on histologic examination. Stool antigen test had good sensitivity (71%) and specificity (82%) for H. pylori detection compared with standard histological diagnosis.
Conclusion: Overall prevalence of H. pylori was 56% and was more common in patients of age > 44 years with dyspepsia. Stool antigen has a good diagnostic accuracy and can be used in resource limited settings. However, we recommend a community based study in larger population.
How to Cite
Copyright © by Nepal Journal of Medical Sciences. The ideas and opinions expressed by authors of articles summarized, quoted, or published in full text in this Journal represents only opinions of authors and do not necessarily reflect the official policy of Nepal Journal of Medical Sciences or the institute with which the author(s) is (are) affiliated, unless so specified.