Old and New Players in Oral Antiplatelet Therapy in Treatment of Acute Coronary Syndrome

  • SC Kohli Department of Medicine, Manipal College of Medical sciences, Pokhara
Keywords: Acute Coronary Syndrome, antiplatelet therapy, thienopyridines

Abstract

Oral antiplatelet therapy plays an important role in treating patients with acute coronary syndrome (ACS), including patients with unstable angina (UA), non-ST segment elevation myocardial infarction (NSTEMI) and patients with ST-segment elevation myocardial infarction (STEMI). All antiplatelet drugs in addition to inhibiting acute arterial thrombosis have danger of interfering with the physiologic role of platelet hemostasis. Bleeding is a major factor in evaluating the utility of available and upcoming antiplatelet drugs and their combination regimes. The role of anti platelet agents in the treatment of ACS has undergone significant changes over the past several years. Aspirin, thienopyridines, and glycoprotein (GP) IIb/IIIa inhibitors are now standard parts of the treatment of STEMI, NSTEMI and UA whether an early invasive or an initial conservative strategy is chosen. Antiplatelet drugs have an important role in secondary prevention in the patients of ischaemic heart disease.

Keywords: Acute Coronary Syndrome; antiplatelet therapy; thienopyridines.

DOI: http://dx.doi.org/10.3126/njms.v1i1.5799  

Nepal Journal of Medical Sciences. 2012; 1(1): 49-55

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How to Cite
Kohli, S. (1). Old and New Players in Oral Antiplatelet Therapy in Treatment of Acute Coronary Syndrome. Nepal Journal of Medical Sciences, 1(1), 49-55. https://doi.org/10.3126/njms.v1i1.5799
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Review Articles