Effect of Antibiotic Pretreatment on Cerebrospinal Fluid Profiles of Children with Acute Bacterial Meningitis

Authors

  • S Adhikari Department of Paediatrics, Manipal College of Medical Sciences, Pokhara
  • E Gauchan Department of Paediatrics, Manipal College of Medical Sciences, Pokhara
  • G BK Department of Paediatrics, Manipal College of Medical Sciences, Pokhara
  • KS Rao Department of Paediatrics, Manipal College of Medical Sciences, Pokhara

DOI:

https://doi.org/10.3126/njms.v2i2.8963

Keywords:

Antibiotic pretreatment, bacterial meningitis, cerebrospinal fluid

Abstract

Background: Analysis of cerebrospinal fluid is gold standard for diagnosis of meningitis. There is considerable difficulty in interpreting laboratory finding after prior antibiotic therapy. This study was conducted to evaluate the effect of intravenous antibiotic administration before lumbar puncture on cerebrospinal fluid profiles in children with bacterial meningitis.

Methods: A hospital based retrospective study carried out using the data retrieved from the medical record department of Manipal Teaching Hospital Pokhara, Nepal; from 1st July 2006 to 31st July 2011. Clinical findings and relevant investigations were entered in a predesigned proforma. Patients were divided in two different groups as bacterial meningitis with and without prior intravenous antibiotic therapy. Various laboratory parameters including CSF were compared between these two groups using the statistical software, SPSS version 18.0.

Results: A total of 114 children were included in this study among which 49(43%) children had received intravenous antibiotics before lumbar puncture. Mean CSF WBC count was(267.6± 211 vs. 208.1±125.3.3) and protein level (114.1±65.9 vs. 98.3±37.7mg/dl) in untreated vs. pretreated groups respectively. Neutrophil percentage was decreased (57.1±28.1vs.72.9±18.9) with higher CSF sugar level (43.3±11.8 vs. 51.2±13.2) after prior antibiotics therapy (p<0.001).

Conclusion: Antibiotic pretreatment was associated with higher cerebrospinal fluid glucose levels with decreased neutrophils and increased lymphocytes. Pretreatment did not modify total cerebrospinal fluid white blood cell count and cerebrospinal fluid protein levels.

Nepal Journal of Medical Sciences | Volume 02 | Number 02 | July-December 2013 | Page 135-139

DOI: http://dx.doi.org/10.3126/njms.v2i2.8963

Downloads

Download data is not yet available.
Abstract
1248
PDF
5187

Downloads

Published

2013-10-23

How to Cite

Adhikari, S., Gauchan, E., BK, G., & Rao, K. (2013). Effect of Antibiotic Pretreatment on Cerebrospinal Fluid Profiles of Children with Acute Bacterial Meningitis. Nepal Journal of Medical Sciences, 2(2), 135–139. https://doi.org/10.3126/njms.v2i2.8963

Issue

Section

Original Articles