Identification and Antimicrobial Susceptibility Pattern of Clinically Significant Coagulase-negative Staphylococci
Keywords:antimicrobial susceptibility testing, coagulase-negative staphylococci (ConS), nosocomial pathogens
AbstractAims: This study was undertaken to determine the prevalence and pathogenicity of coagulase-negative staphylococci in clinical samples and to study the antibiotic-sensitivity pattern of the coagulase-negative isolates.
Methods: A prospective study was conducted over a period of two years on patients admitted in the Sher-i-Kashmir Institute of Medical Sciences. Blood, urine, pus, catheter tips, cerebrospinal fluid and peritoneal fluid samples of patients who fulfilled the criteria for being labeled as nosocomial were cultured.
Results: One hundred and six strains of coagulase negative staphylococci were isolated from the samples and among them 90 isolates were identified as Staphylococcus epidermidis (84.90%). Most of the coagulase-negative staphylococci isolates were resistant to penicillin, cephalosporins and fluoroquinolones. Methicillin resistance was found in a significant number of coagulase-negative isolates. All the isolates were found to be sensitive to vancomycin.
Conclusions: The results of the study emphasized that isolation of coagulase-negative staphylococci should be viewed with serious concern and accurate species identification and antimicrobial susceptibility testing should be performed in all cases.DOI: http://dx.doi.org/10.3126/njog.v9i2.11769
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