Prognosis and recurrence pattern of patients with cervical carcinoma and pelvic lymph node metastasis

Authors

  • Eliza Shrestha State Key Laboratory of oncology in Southern China
  • Xiong Ying State Key Laboratory of oncology in Southern China and Department of Gynecologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou
  • Liang Li-Zhi State Key Laboratory of oncology in Southern China and Department of Gynecologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou
  • Zheng Min State Key Laboratory of oncology in Southern China and Department of Gynecologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou
  • Wang Luang-Hong State Key Laboratory of oncology in Southern China and Department of Gynecologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou
  • Deng Peng-Fei State Key Laboratory of oncology in Southern China and Department of Gynecologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou
  • Liu Ji-Hong State Key Laboratory of oncology in Southern China and Department of Gynecologic Oncology, Cancer Center, Sun Yat-sen University, Guangzhou

Keywords:

Cervical neoplasms, lymph node metastasis, prognosis

Abstract

Aim: To investigate the prognostic risk factor(s) and pattern of disease relapse of patients with cervical
carcinoma and pelvic node metastasis.
Methods: One hundred twenty four cases of FIGOIB1~IIA cervical carcinoma with pelvic node metastasis
treated from January 1991 to December 2001 were selected for this study. Prognosis and recurrence were
retrospectively analyzed using the clinico-pathological data.
Results: The overall 5 year survival and disease-free survival (DFS) was 63.3% and 61.4% respectively.
Overall recurrence rate was 39.5% (49/124). Intra-pelvic relapse (25/41, 61.0%) was significantly more
frequent than extra-pelvic relapse (13/41, 1.7%, P=0.008). Multivariate analysis identified involvement of
common iliac node as independent prognostic factor (P=0.035). According to this factor, node-positive
patients could be divided into low risk group (without common iliac node involvement, 104 cases) and high
risk group (with common iliac node involvement, 20 cases). The DFS were 69.4% and 24.5% respectively,
and the difference was significant (P=0.003). Intra-pelvic relapse was observed in 22.1% of low risk and
25.0% of high risk group respectively, the difference was not significant (P>0.05), however extra-pelvic
relapse was seen in 7.7% of low risk and 40.0% of high risk group, and the difference was significant
(P<0.001).
Conclusions: Common iliac node involvement is the significant factor that influences the prognosis of
patients with cervical carcinoma and pelvic node metastasis. According to this factor, survival and recurrence
pattern differs significantly. These findings provide important reference for individualized modification and
investigation of treatment mode.

Keywords: Cervical neoplasms; lymph node metastasis; prognosis

DOI: 10.3126/njog.v4i1.3327

Nepal Journal of Obstetrics and Gynaecology June-July 2009; 4(1): 19-24

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How to Cite

Shrestha, E., Ying, X., Li-Zhi, L., Min, Z., Luang-Hong, W., Peng-Fei, D., & Ji-Hong, L. (2010). Prognosis and recurrence pattern of patients with cervical carcinoma and pelvic lymph node metastasis. Nepal Journal of Obstetrics and Gynaecology, 4(1), 19–24. Retrieved from https://www.nepjol.info/index.php/NJOG/article/view/3327

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