Ramalin, a Novel Phenyl Hydrazide from the Lichen Ramalina Terebrata; Isolation, Total Synthesis and Biological Activities

Authors

  • Durga Prasad pandey Research Centre for Applied Science and Technology, Tribhuvan University, Kirtipur, Kathmandu
  • Hari Datta Bhattarai

DOI:

https://doi.org/10.3126/tuj.v30i2.25544

Keywords:

Antioxidant, ramalin, Ramalina terebrata, total synthesis

Abstract

Ramalin, a new L-glutamic acid derivative of phenylhydrazide (Y-glutamyl-N'-(2-hydroxyphenyl) hydrazide, 1) was isolated from the Antarctic lichen, Ramalina terebrata after a series of bioactivity guided fractionation of crude aqueous methanolic extract. Ramalin showed stronger antioxidant activities than commercially available standards, ascorbic acid, trolox, BHA, kojic acid in both, in vitro and in vivo test systems. In addition, ramalin showed no/less toxicity effects against two human cell lines; fibroblast (CCD-986SK) cells and keratinocyte (HaCaT). Thus, realign merits for cosmetic application and industrial scale production were needed. We developed a cost effective total synthesis of ramalin with 71.5% yield and described here.

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Author Biographies

Durga Prasad pandey, Research Centre for Applied Science and Technology, Tribhuvan University, Kirtipur, Kathmandu

Reader in Chemistry 

Hari Datta Bhattarai

Freelance Researcher

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Published

2016-12-01

How to Cite

pandey, D. P., & Bhattarai, H. D. (2016). Ramalin, a Novel Phenyl Hydrazide from the Lichen Ramalina Terebrata; Isolation, Total Synthesis and Biological Activities. Tribhuvan University Journal, 30(2), 35–42. https://doi.org/10.3126/tuj.v30i2.25544

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Articles