Research on Covid-19 from Biophysical Perspective

  • Tika Ram Lamichhane Central Department of Physics, Tribhuvan University, Kathmandu, Nepal
  • Madhav Prasad Ghimire Central Department of Physics, Tribhuvan University, Kathmandu, Nepal
Keywords: coronavirus, structural analysis, mathematical and clinical data modeling, drugs, viral proteins, COVID-19

Abstract

 In this report, we discuss the current aspect of biophysics which is an essential field to investigate the structural and related properties of SARS-CoV-2 components, possible drugs likeliness and their interactions, and mathematical as well as clinical data modeling. We have emphasized that a mathematical model generates the sigmoid logistic equation that predicts the total corona virus cases and deaths in a model country with population averaged from the most vulnerable countries, such as India or USA, where the COVID-19 cases are still spiking up and from the countries which are on the process of recovering from the current pandemic. Further, the current status of COVID-19 research has been explained to understand its impacts taking Nepal as the reference country having low-income. In particular, focus is on biophysical study on structural analysis of novel coronavirus main protease which is found to influence the radial distributions of H-bonding atom pairs when interacting with the inhibitors N3. Explorations of the variations of physical parameters are found to be important in drug selective mechanism against COVID-19 infections.

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Author Biography

Madhav Prasad Ghimire, Central Department of Physics, Tribhuvan University, Kathmandu, Nepal

Condensed Matter Physics Research Center, Butwal-11, Rupandehi, Lumbini, Nepal

Published
2020-09-27
How to Cite
Lamichhane, T., & Ghimire, M. (2020). Research on Covid-19 from Biophysical Perspective. Tribhuvan University Journal, 34, 1-14. https://doi.org/10.3126/tuj.v34i0.31535