Research Progress on the effect of radiotherapy on immune function of tumor patients

Authors

  • Wenxin Li Departments of Oncology, Affiliated Hospital of Chengde Medical College,36 Nanyingzi Street, Shuangqiao, Chengde,Hebei 067000, P.R. China
  • Xiaolei Yu Xiaolei Yu, Departments of Oncology,Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Shuangqiao, Chengde,Hebei 067000, P.R. China
  • Qingshan Li Departments of Radiology, Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Shuangqiao, Chengde,Hebei 067000, P.R. China
  • Fan Xu Departments of Oncology, Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Shuangqiao, Chengde,Hebei 067000, P.R. China
  • Sheng Lin Zhang Departments of Oncology , Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Shuangqiao, Chengde,Hebei 067000, P.R. China
  • Xiao Li Departments of Radiology, Affiliated Hospital of Chengde Medical College, 36 Nanyingzi Street, Shuangqiao, Chengde,Hebei 067000, P.R. China

DOI:

https://doi.org/10.3126/njc.v6i1.44208

Keywords:

Radiotherapy, Immune function

Abstract

With the cure rate of 21%, radiotherapy is one of the most effective methods for tumor treatment, and about 70% of solid tumors need radiotherapy.With the in-depth study of human impact by radiotherapy and immune system and tumor microenvironment, radiotherapy is no longer used as a local treatment. It is found that irradiation of tumor can activate body immunity. There exist two different views: one is that radiotherapy inhibits immunity, because it can kill tumor cells and normal cells at the same time.The other is that radiotherapy promotes immunity, causing tumor cell necrosis or apoptosis, releasing immune cytokines or promoting immune cell activation, and bystander effect. In recent years, the idea of radiotherapy promoting immunity has been more and more supported by literatures. Whether radiotherapy promotes or inhibits immunity is a research hot spot in recent years. This paper reviews the research progress of the effect of radiotherapy on immune function of tumor patients.

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Published

2022-04-03

How to Cite

Li, W., Yu, X., Li, Q., Xu, F., Zhang, S. L., & Li, X. (2022). Research Progress on the effect of radiotherapy on immune function of tumor patients. Nepalese Journal of Cancer, 6(1), 42–47. https://doi.org/10.3126/njc.v6i1.44208

Issue

Section

Review Articles