Protective effect of Esculetin on myocardial injury induced by doxorubicin

Authors

  • Fan Xu Department of Oncology, Affiliated Hospital of Chengde Medical College, P R of China
  • Xiao Li Department of Radiology, Affiliated Hospital of Chengde Medical College, P R of China
  • Xiaolei Yu Department of Oncology, Affiliated Hospital of Chengde Medical College, P R China

DOI:

https://doi.org/10.3126/njc.v6i2.48773

Keywords:

Esculetin, Myocardial injury, Collagen fiber, Doxorubicin

Abstract

Objective: To study the protective effect of Esculetin on myocardial injury induced by doxorubicin and explore the mechanism of doxorubicin on myocardial injury in rats.

Methods: Doxorubicin(2.5mg/kg) was injected intraperitoneally every other day for 6 times to establish a rat model of myocardial injury. The effects of different doses of Esculetin (10mg/kg & 20mg/kg) on serum myocardial enzymes and myocardial tissue were observed.

Results: Doxorubicin significantly increased serum myocardial enzymes and the content of myocardial interstitial collagen fibers in mice. Different doses of Esculetin could reduce myocardial injury in a dose-dependent manner.

Conclusion: Esculetin has a protective effect on myocardial injury induced by doxorubicin.

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Published

2022-10-06

How to Cite

Xu, F., Li, X., & Yu, X. (2022). Protective effect of Esculetin on myocardial injury induced by doxorubicin. Nepalese Journal of Cancer, 6(2), 79–28. https://doi.org/10.3126/njc.v6i2.48773

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Section

Original Articles