Effect of Neonatal Exposure of Monosodium Glutamate in Kidney of Albino Mice – A Histological Study

  • Tapati Bhattacharya Medical College Kolkata 88 College Street, India
  • S.K. Ghosh Nepal Medical College Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu, Nepal
Keywords: Monosodium Glutamate (MSG), proximal convoluted tubules (PCT), distal convoluted tubules (DCT), glomerulus

Abstract

 Monosodium Glutamate (MSG) is a commonly used food additive. Scientists have found that MSG has toxic effects in several tissues and organs like neurons, liver, testes, ovary, kidneys etc due to oxidative stress both after exposure in neonatal period as well as in adult animal models. Although various reports have suggested that MSG has damaging effect in kidneys only few histological studies are available. This study was done to observe any histological changes in kidneys of albino mice after neonatal exposure with MSG. Study showed significant changes in weight and volume of kidneys in gross morphology. Increased urinary space and dilatation of proximal convoluted tubules (PCT) and distal convoluted tubules (DCT) were constant finding in experimental animals. There were loss of luminal microvilli and reduced height of lining cells of both PCT and DCT.

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Author Biographies

Tapati Bhattacharya, Medical College Kolkata 88 College Street, India

Associate Professor, Department of Anatomy

S.K. Ghosh, Nepal Medical College Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu, Nepal

Department of Anatomy

Published
2019-08-02
Section
Original Articles