Cardiovascular Risk Assessment in Hemodialysis Patients

Authors

  • Asmita Pokhrel Nepal Medical College and Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu, Nepal https://orcid.org/0000-0002-5739-6056
  • Buddhi Raj Pokhrel Universal College of Medical Sciences, Bhairahawa, Nepal
  • Prajwal Gyawali University of Newcastle, New South Wales, Australia
  • Deepak Regmi Nepal Medical College & Teaching Hospital, Kathmandu Nepal
  • Madhav Khanal Nepal Medical College & Teaching Hospital, Kathmandu Nepal
  • Ashim Bhattarai Institute of Medicine, Maharajgunj, Nepal
  • Prakash Poudel Nepal Medical College and Teaching Hospital, Kathmandu, Nepal
  • Anil KC Nepal Medical College and Teaching Hospital, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/nmcj.v23i3.40385

Keywords:

Hemodialysis, Homocysteine, high sensitive C-reactive protein, oxidized LDL antibody, Red cell distribution width

Abstract

Cardiovascular diseases are the leading cause of death in hemodialysis patients. We aimed to evaluate non-traditional cardiovascular risk factors: homocysteine, high sensitive C-reactive protein, oxidized LDL antibodies, phosphate, and red cell distribution width in chronic kidney disease patients under maintenance hemodialysis along with traditional cardiovascular risk factors like age, hypertension, diabetes mellitus, among others. A total of 78 diagnosed chronic kidney disease patients under maintenance hemodialysis visiting a tertiary care center were included in the study, of which 59% were male. Hyperhomocysteinemia was present in 79.5% of the participants, with the median homocysteine level being 28.43 μmol/L. The median hsCRP level was 4.74 mg/L, and 59% and 24.4% of the total participants were at high and moderate cardiovascular risk respectively. The median oxidized LDL antibody level was 4235 U/mL, which is within the reference range. The median red cell distribution width was 14.05%, which is within the normal range. Left ventricular hypertrophy, a common cardiovascular disease in such patients, was found in 55.13% of the participants. Serum homocysteine level was significantly higher in patients with left ventricular hypertrophy, whereas serum C- reactive protein level was significantly lower in patients with left ventricular hypertrophy. The mean serum phosphate was 6.23 mg/dL (i.e. higher than normal) and hyperphosphatemia was seen among 76.9% of the patients. The mean age of the patients was 47.5 years, which is distinctly lower when compared to the hemodialysis patients in the Western population. The prevalence of hypertension, diabetes mellitus, and anemia were 95%, 18.25%, and 92.3%, respectively.

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Author Biographies

Asmita Pokhrel, Nepal Medical College and Teaching Hospital, Attarkhel, Gokarneshwor-8, Kathmandu, Nepal

Assistant Professor, Department of Biochemistry

Buddhi Raj Pokhrel, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Biochemistry

Prajwal Gyawali, University of Newcastle, New South Wales, Australia

Priority Research Centre for Stroke and Brain Injury, School of Biomedical Sciences and Pharmacy

Madhav Khanal, Nepal Medical College & Teaching Hospital, Kathmandu Nepal

Department of Biochemistry

Ashim Bhattarai, Institute of Medicine, Maharajgunj, Nepal

Department of Biochemistry

Prakash Poudel, Nepal Medical College and Teaching Hospital, Kathmandu, Nepal

Hemodialysis unit, Department of Medicine

Anil KC, Nepal Medical College and Teaching Hospital, Kathmandu, Nepal

Hemodialysis unit, Department of Medicine

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Published

2021-10-17

How to Cite

Pokhrel, A., Pokhrel, B. R., Gyawali, P., Regmi, D., Khanal, M., Bhattarai, A., Poudel, P., & KC, A. (2021). Cardiovascular Risk Assessment in Hemodialysis Patients. Nepal Medical College Journal, 23(3), 252–258. https://doi.org/10.3126/nmcj.v23i3.40385

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Section

Original Articles