Evaluation of Efficacy of Serum Adenosine Deaminase Values for Detection of Pulmonary and Extra Pulmonary Tuberculosis

Authors

  • Parishrut Prasad Pandey Kathmandu University
  • Vedhant Jaiswal Kathmandu University
  • Tara Nath Sharma Kathmandu University
  • Shreeju Vaidhya KIST Medical College
  • Adhyashree Karki KIST Medical College
  • Bibesh Dahal Kanti Childrens Hospital
  • Manohar Pradhan Kathmandu University

DOI:

https://doi.org/10.3126/jcmsn.v20i2.66324

Keywords:

ADA; tuberculosis; extrapulmonary TB (EPTB).

Abstract

Background
Tuberculosis is one of the leading cause of morbidity and mortality worldwide and in Nepal. Despite advances in its diagnosis, majority of the cases still go undetected. These account for sputum smear negative and extra pulmonary cases where demonstration of the microorganism is challenging. ADA an enzyme found in all mammalian species is found raised in various effusion body fluids of organs affected by the disease. Time tested studies have also shown that serum values of ADA are elevated in patients affected with the disease thus can aid as supportive evidence in doubtful cases.
Methods
An Analytical cross sectional Hospital Based study involving 110 with 75 cases and 35 healthy participants was conducted in College of Medical Sciences for 5 months from January to June 2024. Serum ADA levels were measured in all participants, diseased and healthy and collected data was analyzed for significance.
Results
The mean Serum ADA level in TB patients was found to be 47.01 and that of healthy participants was 14.68. Significant difference in the mean serum ADA level between TB and non TB patients (p-value < 0.001) was found concluding that TB patients have high serum ADA level. Comparisons between mean serum ADA levels in Different types of TB found no significant difference among them with all p- values in each pair being more than 0.5 suggesting that serum ADA levels rise in all forms of TB.
Conclusions
Serum ADA values are raised in all forms of tuberculosis and can serve as a supportive evidence in patients with Smear negative and Extrpulonary TB where microorganisms is difficult to demonstrate. However further validation need to be done by more studies in the future.

Downloads

Download data is not yet available.
Abstract
88
PDF
83

Author Biographies

Shreeju Vaidhya, KIST Medical College

Associate professor

Adhyashree Karki, KIST Medical College

Associate professor 

Manohar Pradhan, Kathmandu University

Head of Department, Department of General Practice and Emergency Medicine

Downloads

Published

2024-06-30

How to Cite

Pandey, P. P., Jaiswal, V., Sharma, T. N., Vaidhya, S., Karki, A., Dahal, B., & Pradhan, M. . (2024). Evaluation of Efficacy of Serum Adenosine Deaminase Values for Detection of Pulmonary and Extra Pulmonary Tuberculosis . Journal of College of Medical Sciences-Nepal, 20(2), 114–118. https://doi.org/10.3126/jcmsn.v20i2.66324

Issue

Section

Original Articles