Expressions of HPV 16-E6 in esophageal carcinoma and it’s clinical significance

  • Zhao Xing Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • R Sahi B.P. Koirala Memorial Cancer Hospital, Chitwan
  • Zhao Yu-Yang Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Wang Jun Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
  • Chun-Hui Li Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei Province
Keywords: Esophageal carcinoma, HPV 16-E6, Immunohistochemistry

Abstract

Background?Gastrointestinal cancer is the most common malignant tumor in China. This research aims to explore the association between HPV16-E6 protein and esophageal squamous cell carcinoma.

Materials and Methods: SP immunohistochemical method was used to examine the expression of HPV 16-E6 in 50 cases of esophageal squamous cell carcinoma, 10 cases of normal esophageal squamous cell and 10 cases of adjacent tissue.

Results: The expressions of HPV 16-E6 was significantly higher in esophageal carcinoma than in normal esophageal mucosa and in adjacent tissue. The expressions of HPV 16-E6 had correlation with invasive depth (P<0.05), but not with patient age, lymph node metastasis, tumor size (P>0.05).

Conclusion: HPV 16-E6 can promote the growth and metastasis of esophageal squamous cell carcinoma and can be a prognostic factor of esophageal squamous cell carcinoma.

Journal of Pathology of Nepal (2015) Vol. 5, 752-755

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Abstract
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Published
2015-03-27
How to Cite
Xing, Z., Sahi, R., Yu-Yang, Z., Jun, W., & Li, C.-H. (2015). Expressions of HPV 16-E6 in esophageal carcinoma and it’s clinical significance. Journal of Pathology of Nepal, 5(9), 752-755. https://doi.org/10.3126/jpn.v5i9.13786
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Original Articles