T-cell lymphoblastic lymphoma with generalized lymphadenopathy and bone marrow involvement

  • AD Pant Grande International Hospital, Dhapasi, Kathmandu, NEPAL
Keywords: Lymphoma, Bone marrow, Lymph node, Immunohistochemistry

Abstract

A 16-year-old girl presented to the out patient department in Grande International Hospital with complaints of fever since 3 weeks, tonsillitis and multiple lymphadenopathy.  Fine needle aspiration cytology from one of the cervical lymph nodes showed atypical lymphoid cells with prominent nucleoli in some cells; hence, a diagnosis of Non Hodgkin lymphoma was made.  Bone marrow aspiration and biopsy also showed presence of similar atypical lymphoid cells.  One of the lymph nodes was also excised for purpose of immunohistochemistry, and the biopsy showed effacement of lymph node architecture with diffuse proliferation of intermediate sized atypical lymphoid cells.  These tumor cells showed positivity for CD3, TdT, and Ki-67.  A diagnosis of T-cell lymphoblastic lymphoma was made.

Lymphoblastic lymphomas are rare, accounting for 2% of all lymphomas, of which majority are of T-cell type.  TCLL usually occurs in young males.  In addition to lymphadenopathy, other common sites of involvement include mediastinum, CNS and bone marrow.  It runs an aggressive course and overall survival of patients is poor.

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Author Biography

AD Pant, Grande International Hospital, Dhapasi, Kathmandu, NEPAL
Department of Pathology and Laboratory Medicine,
Published
2015-09-14
How to Cite
Pant, A. (2015). T-cell lymphoblastic lymphoma with generalized lymphadenopathy and bone marrow involvement. Journal of Pathology of Nepal, 5(10), 875-878. https://doi.org/10.3126/jpn.v5i10.15667
Section
Case Reports