Intubating Conditions with Rocuronium Bromide and Suxamethonium in Elective Surgeries: A Randomized Comparative Study
Keywords:Rocuronium, succinylcholine, Tracheal intubating condition
INTRODUCTION: Adequate intubating condition is required to avoid airway trauma and adverse sympathetic responses. Though, Succinylcholine is considered as ideal drug, it has many contraindications. In search of alternative, rocuronium is found to have similar responses in higher doses. Therefore, our aim was to compare the effect of different dosages of rocuronium with sucinylcholine for tracheal intubation and the haemodynamic variables.
MATERIAL AND METHODS: A prospective randomized comparative study was conducted in Universal College of Medical Sciences (UCMS-TH) in 90 (American Society of Anaesthesiologists Physical Status I and II) patients with age between 18 to 60 years scheduled for elective surgeries under general anesthesia. They were divided into 3 groups of 30 each using lottery system. Groups 1 and 2 received intravenous rocuronium 0.6mg/kg and 1mg/kg respectively whereas patients in group 3 received intravenous succinylcholine 1.5mg/kg. Under continuous monitoring, tracheal intubation attempt was done at 60 seconds after the administration of drug and intubating conditions were assessed according to Cooper et al four point scale.
RESULTS: Only 26.7% of patients in group 1 exhibited excellent intubating condition whereas in groups 2 and 3, excellent intubating condition was exhibited in 100% when muscle relaxant was administered at 60 seconds with highly significant statistical difference between groups 1 and 3 with p value <0.001 without any adverse effects in any of these patients.
CONCLUSION: This study concluded that intubating response with inj. succinylcholine 1.5mg/kg is similar to rocuronium 1.0mg/kg and is superior to inj rocuronium 0.6mg/kg, for intubating condition at 60 seconds following the drug administration while using Cooper et al. Score.
How to Cite
Authors have to give the following undertakings along with their article:
- I/we declare that this article is original and has not been submitted to another journal for publication.
- I/we declare that I/we surrender all the rights to the editor of the journal and if published will be the property of the journal and we will not publish it anywhere else, in full or part, without the permission of the Chief Editor.
- Institutional ethical and research committee clearance certificate from the institution where work/research was done, is required to be submitted.
- Articles in the Journal are Open Access articles published under the Creative Commons CC BY-NC License (https://creativecommons.org/licenses/by-nc/4.0/)
- This license permits use, distribution and reproduction in any medium, provided the original work is properly cited, and it is not used for commercial purposes.