Treatment Non-Compliance in Patients with Schizophrenia

  • Sandip Subedi Department of Psychiatry, Universal College of Medical Sciences, Bhairahawa, Nepal
  • Kamala Paudel Psychiatry Nursing, Manmohan Memorial Institute of Health Sciences, Kathmandu
  • Dev Kumar Thapa Department of Psychiatry, Gandaki Medical College, Pokhara
Keywords: Schizophrenia, compliance, non-compliance, factors affecting compliance


INTRODUCTION: Non-compliance to medication in Schizophrenia is a common problem.  It leads to frequent recurrence of Psychosis which has negative impact on individuals and their families. Understanding and reducing non-adherence is therefore a key challenge to quality care for patients with Schizophrenia. This study was conducted with the aim of determining the incidence and factors associated with medication non-compliance among patients suffering from schizophrenia.

MATERIAL AND METHODS: This cross-sectional study included 94 schizophrenic subjects who visited psychiatric OPD of tertiary level hospital. Disproportionate stratified random sampling method was applied to collect the data. Socio-demographic data sheet, data sheet to collect the various factors of compliance and the 8-item Morisky Medication Adherence Scale (MMAS-8) were used for data collection by interview method. 

RESULTS: The prevalence of non-compliance was 89.4%. With regards to association between noncompliance and demographic characteristics, there was high non-compliance rate in age below 40 years (54.2%), male (52.1%), married (64.8%) and low economic status (52%). Medication non-compliance were high in patients with medication side effects dizziness (60.6%), sedation (66%), longer duration of illness (92.8%) & having 1-3 pills (47.8%).

CONCLUSION: Medication Non-Compliance in Schizophrenia was high. Measures that can increase compliance like psycho-educational programmes on compliance and the active involvement of the relatives and significant others in the management of patients of mentally ill patients are recommended.

How to Cite
Subedi, S., Paudel, K., & Thapa, D. (2020). Treatment Non-Compliance in Patients with Schizophrenia. Journal of Universal College of Medical Sciences, 8(1), 3-8.
Original Articles