Serum Vitamin D and B12 Levels in Alcoholic Male Patients: A Cross-sectional Study

Authors

  • Archana Jayan Universal College of Medical Sciences, Bhairahawa, Nepal
  • Buddhi Raj Pokhrel Universal College of Medical Sciences, Bhairahawa, Nepal
  • Narayan Gautam Universal College of Medical Sciences, Bhairahawa, Nepal
  • Amit Chandra Jha Universal College of Medical Sciences, Bhairahawa, Nepal
  • Binaya Tamang Universal College of Medical Sciences, Bhairahawa, Nepal
  • Jharana Shrestha Universal College of Medical Sciences, Bhairahawa, Nepal
  • Sanjeev Ranjan Universal College of Medical Sciences, Bhairahawa, Nepal
  • Raju Kumar Dubey Maharajgunj Medical Campus, Kathmandu, Nepal

DOI:

https://doi.org/10.3126/jucms.v9i01.37976

Keywords:

Alcoholism, Liver function parameters, Vitamin B12, Vitamin D

Abstract

INTRODUCTION

Alcohol dependence is a global problem and is rapidly increasing in developing countries. We aimed to analyze the serum levels of vitamin B12 and vitamin D in chronic alcoholic patients and their association with parameters of liver function.

MATERIAL AND METHODS

A cross-sectional study was carried out in Universal College of Medical Sciences, Bhairahawa, Nepal from March 2020 to September 2020 on patients visiting the Psychiatric Out Patient Department (OPD) for the treatment of alcohol dependence. The patients were categorized as excessive and moderate drinkers. Serum vitamin B12, vitamin D, and hepatic function parameters were measured.

RESULTS

The median serum vitamin B12 and vitamin D levels were 467.8 pg/ml and 24.9 ng/ml respectively. Excessive drinkers had significantly higher B12   levels than moderate drinkers. Vitamin B12   levels correlated positively with liver function parameters, as well as alcohol amount and duration of consumption. Vitamin D levels were insufficient in 57 (71.25%) of the overall participants.

CONCLUSION

Serum levels of vitamin B12 are not affected in patients with alcohol dependence. Alcohol consumption, however, reduces serum concentrations of vitamin D. Vitamin B12  concentration is positively associated with liver enzymes and other parameters of liver function.

 

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Author Biographies

Archana Jayan, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Biochemistry

Buddhi Raj Pokhrel, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Biochemistry

Narayan Gautam, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Biochemistry

Amit Chandra Jha, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Biochemistry

Binaya Tamang, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Biochemistry

Jharana Shrestha, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Biochemistry

Sanjeev Ranjan, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Psychiatry

Raju Kumar Dubey, Maharajgunj Medical Campus, Kathmandu, Nepal

Department of Biochemistry

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Published

2021-06-22

How to Cite

Jayan, A., Pokhrel, B. R., Gautam, N., Jha, A. C., Tamang, B., Shrestha, J., Ranjan, S., & Dubey, R. K. (2021). Serum Vitamin D and B12 Levels in Alcoholic Male Patients: A Cross-sectional Study. Journal of Universal College of Medical Sciences, 9(01), 47–51. https://doi.org/10.3126/jucms.v9i01.37976

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Section

Original Articles