Formulation and In-Vitro Evaluation of Gastro-Retentive Floating Tablet of Furosemide

Authors

  • Pradyumna Chaudhari Universal College of Medical Sciences, Bhairahawa, Nepal
  • Deepak G.R. Universal College of Medical Sciences, Bhairahawa, Nepal
  • Roshan Kumar Mehta Universal College of Medical Sciences, Bhairahawa, Nepal

DOI:

https://doi.org/10.3126/jucms.v13i03.88799

Keywords:

Furosemide, Gastro-retentive drug delivery system, Direct compression method

Abstract

INTRODUCTION
4-chloro-2-(furan-2-ylmethylamino)-5-sulfamoylbenzoic acid (Furosemide) is high efficacious diuretic, used to treat edema and congestive heart failure. Gastro retentive floating tablets offer advantages by retaining in the stomach for a sufficient time against all physiological barriers. It improves bioavailability, reduces drug wastages, and improve the solubility of drug in high pH environment. The crucial aspect is to increase the dissolution time.

 MATERIAL AND METHODS
An experimental design was done in the pharmaceutic laboratory of department of pharmacy from August 2022 to January 2023. Gastro-retentive floating tablets were prepared by direct compression method using different viscosity grades of polymers with sodium bicarbonate and were lubricated with magnesium stearate and talc. The parameters before and after compression were evaluated.

RESULTS
All the hydro-dynamically balanced system formulations showed good in-vitro floating properties. The tablet of F4 formulation was best which shows drug release up to 12 hours with percentage cumulative drug release up to 99.04 %.

CONCLUSION
The preparation shows successful approach to maintain the sustain release of furosemide at different time interval. Among formulations, floating tablet formulated using 100 mg Hydroxypropyl methylcellulose K15 M (HPMC K15M) polymer was found to be best.

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Author Biographies

Pradyumna Chaudhari, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Pharmacy

Deepak G.R., Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Pharmacy

Roshan Kumar Mehta, Universal College of Medical Sciences, Bhairahawa, Nepal

Department of Pharmacology

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Published

2025-12-31

How to Cite

Pradyumna Chaudhari, Deepak G.R., & Roshan Kumar Mehta. (2025). Formulation and In-Vitro Evaluation of Gastro-Retentive Floating Tablet of Furosemide. Journal of Universal College of Medical Sciences, 13(03), 18–23. https://doi.org/10.3126/jucms.v13i03.88799

Issue

Vol. 13 No. 03 (2025): Issue 35

Section

Original Articles

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