Epidemiologic characteristics, clinical management and Public Health Implications of Coronavirus Disease 2019 (COVID-19) in Pregnancy: A Systematic Review and meta-analysis

Authors

DOI:

https://doi.org/10.3126/nje.v11i4.41911

Keywords:

Pandemic, Pregnancy, Childbirth, Complications, Clinical Management, Prevention

Abstract

Background:  The novel coronavirus disease 2019 (COVID-19) outbreak, caused by the pathogenic severe acute respiratory syndrome-2 (SARS-CoV-2) virus, is exponentially spreading across the globe.

Methods: The current systematic review was performed utilizing electronic databases i.e. PubMed, MEDLINE and EMBASE. We searched for the keywords "COVID-19 AND "pregnancy" between January 1st, 2020 until December 31, 2020.

Results: Out of 4005 records which were identified, 36 original studies were included in this systematic review. Pooled prevalence of vertical transmission was 10%, 95% CI: 4-17%. Pooled prevalence of neonatal mortality was 7%, 95% CI: 0-21%.

Conclusion: The contemporary evidence suggests that the incubation period of COVID-19 is 2-14 days, and this infection could be transmitted even from the infected asymptomatic individuals. It is found that the clinical presentation of pregnant women with COVID-19 infection is comparable with the infected non-pregnant females, and the frequent symptoms were fever, cough, myalgia, sore throat and malaise. There are some cases with severe maternal morbidity and perinatal deaths secondary to COVID-19 infection. Under these circumstances, the pregnant women should focus on maintaining personal hygiene, proper nutrition and extreme social distancing to reduce the risk of COVID-19. Therefore, a systematic data reporting for evidence base clinical assessment, management and pregnancy outcomes is essential for prevention of COVID-19 infection among pregnant women.

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Author Biographies

Brijesh Sathian, Geriatrics and long term care Department, Rumailah Hospital, Doha, Qatar

PhD, Scientist

Indrajit Banerjee, Sir Seewoosagur Ramgoolam Medical College, Belle Rive, Vacoas-Phoenix, Mauritius

MD, Associate Professor

Ahammed A Mekkodathil, Surgery Department, Trauma Surgery, Hamad General Hospital, Doha, Qatar

MPH

Edwin van Teijlingen, Centre for Midwifery, Maternal and Perinatal Health, Bournemouth University, Bournemouth, United Kingdom

PhD, Professor

Mohammad Asim, Surgery Department, Trauma Surgery, Hamad General Hospital, Doha, Qatar

PhD

Maraeh Angela Mancha, Geriatrics and long term care Department, Rumailah Hospital, Doha, Qatar

BSN

Russell Kabir, School of Allied Health, Faculty of Health, Education, Medicine, and Social Care, Anglia Ruskin University, Chelmsford, United Kingdom.

PhD

Padam Simkhada, School of Human and Health Sciences, University of Huddersfield, UK

PhD

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Published

2021-12-31

How to Cite

Sathian, B., Banerjee, I., Mekkodathil, A. A., van Teijlingen, E., Pizarro, A. B., Asim, M., Mancha, M. A., Kabir, R., Simkhada, P., Nascimento, I. J. B. do, & Al Hamad, H. (2021). Epidemiologic characteristics, clinical management and Public Health Implications of Coronavirus Disease 2019 (COVID-19) in Pregnancy: A Systematic Review and meta-analysis. Nepal Journal of Epidemiology, 11(4), 1103–1125. https://doi.org/10.3126/nje.v11i4.41911

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Section

Original Articles