Comparison of urine protein creatinine ratio and 24 hours urine protein in detecting preeclampsia

Authors

  • Nesuma Sedhain Paropakar Maternity and Women’s Hospital, Kathmandu
  • Jageshwor Gautam Paropakar Maternity and Women’s Hospital, Kathmandu
  • Gehanath Baral Paropakar Maternity and Women’s Hospital, Kathmandu

Keywords:

preeclampsia, proteinuria, protein-creatinine ratio

Abstract

Aim: To assess the diagnostic accuracy of spot urine protein-creatinine ratio for detection of proteinuria in Preeclampsia.

Methods: Cross Sectional Descriptive Study was conducted in a total of 38 pregnant women in Paropakar Maternity and Women’s Hospital in study period of 3 month. The correlation between protein- creatinine ratio in spot urine samples and urinary protein excretion in 24-hour collections were analyzed.

Results: Comparison of 24 hours urinary protein and protein- creatinine ratio in women with preeclampsia shows a significant correlation (r=0.911, p<0.0001). The cut-off protein-creatinine ratios which gave maximum area under the curve for 300mg protein for 24hrs was 0.27 (sensitivity: 94.6%, specificity: 100%, PPV: 100%, NPV: 33.3%); 2000 mg urine protein excretion was 2.1 (sensitivity and specificity of 100%); 3000mg protein excreted for 24hours was 3.0 (sensitivity: 83.3%,

specificity: 92.3%, PPV: 83.3%, NPV: 93.3%. Area under the ROC for 24hours urine total protein of >300mg, >2000mg and >3000mg/day were 0.946 (95%CI 0.873-1.019), 1 (95% CI 1.00-1.00) and 0.957 (95%CI 0.897- 1.016) respectively.

Conclusions: Spot urine protein-creatinine ratio is as accurate as to 24 hours urine protein determination of proteinuria in Preeclampsia.

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Author Biography

Nesuma Sedhain, Paropakar Maternity and Women’s Hospital, Kathmandu

Department of Obstetrics and Gynaecology

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Published

2019-12-31

How to Cite

Sedhain, N., Gautam, J., & Baral, G. (2019). Comparison of urine protein creatinine ratio and 24 hours urine protein in detecting preeclampsia. Nepal Journal of Obstetrics and Gynaecology, 14(2), 49–53. Retrieved from https://www.nepjol.info/index.php/NJOG/article/view/28439

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Original Articles