Hexane Extract of Rhizomes of Curcuma Longa, Zingiber Officinale and Curcumine Life Span Extension in Caenorhabditis Elegans By Reducing Fat in Intestine

  • Parveen Gazala Department of Pharmacognosy, J.S.S. College of Pharmacy Ooty
  • Basavan Duraiswamy Department of Pharmacognosy, J.S.S. College of Pharmacy Ooty
  • Firoz Ansari Department of Emergency, National Medical College, Birgunj
Keywords: Curcumin, Curcuma longa, Zingiber officinale, Lifespan, Aging, Caenorhabditis elegans

Abstract

Background: Curcumine is obtained from curcuma longa and we examined the effects of curcumin, hexane extracts of Curcuma longa and Zingiber officinale on the lifespan and aging in Caenorhabditis elegans and found that it responded to curcumin, hexane extracts of Curcuma longa and Zingiber officinale with an increased lifespan and reduced intracellular reactive oxygen species during aging.

Methods: MutantStrains, culture, Curcumin and Hexane extract of Rhizomes of Curcuma longa and Zingiber officinale treatment of C. Elegan.

Results: Curcumin and hexane extracts of Curcuma longa and Zingiber officinale increased the life span and life cycle of the N2 wild type and Zdls-5 worms. On comparison, curcumin was found to be the most effective followed by the hexane extracts of Curcuma longa and hexane extracts of Zingiber officinale. Hexane extracts of Zingiber officinale were found to be least effective. Sudan black staining exhibited that stored contents of fat in C.elegans decreased as the concentration of the drug increased.

Conclusions: Our study has established that curcumin and hexane extract of rhizomes of Curcuma longa and Zingiber officinale provides longevity and decreases the fat content in C.elegans.

Med Phoenix. Vol. 3, Issue. 1, 2018, Page: 21-28

                                            

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Abstract
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Published
2018-08-15
How to Cite
Gazala, P., Duraiswamy, B., & Ansari, F. (2018). Hexane Extract of Rhizomes of Curcuma Longa, Zingiber Officinale and Curcumine Life Span Extension in Caenorhabditis Elegans By Reducing Fat in Intestine. Med Phoenix, 3(1), 21-28. https://doi.org/10.3126/medphoenix.v3i1.20757
Section
Research Articles