Alteration of Liver Function Tests following Laparoscopic Cholecystectomy

Abstract

Introduction: Cholelithiasis is a common surgical problem. Laparoscopic cholecystectomy is the gold standard of treatment for symptomatic cholelithiasis. It requires creation of pneumoperitoneum which has some physiological consequences like rise in liver function tests indicating hepatic hypoperfusion and ischemia in patients who were preoperatively normal.

Materials and methods: A prospective observational study was conducted at Pokhara Academy of Health Sciences, Pokhara from March to July 2022. One hundred patients who underwent elective laparoscopic cholecystectomy meeting inclusion criteria were enrolled. Data collection was done using a structured porforma. Stastical analysis was done SPSS version 21. Data were presented as mean and standard deviation. Appropriate statistical tests were applied and p value of <0.05 was considered significant.

Results: Out of hundred patients, twenty nine percent were male and seventy- one percent were female with mean age of 48.87 years. The post-operative day one serum bilirubin ( mean 1.016) ,SGPT-Serum Glutamate Pyruvate Trasaminase (mean 62.56) and SGOT-Serum Glutamic Oxaloacetic transaminase (mean 61.74) were increased as compaired to the pre-operative mean values of 0.649, 34.96, and 35.46 respectively with p value of 0.000 where as mean of post-operative post-oprative day seven values 0.644 , 32.21 , 32.98 were almost near to pre-operative values. Mean of pre-operative(99.03 ) and post-operative(95.75 ) ALP-Alkaline Phosphatase were almost comparable.

Conclusion: There was a transient elevation in serum bilirubin, Serum Glutamate Pyruvate Trasaminase, Serum Glutamic Oxaloacetic Transaminase following laparoscopic cholecystectomy due to carbondioxide pneumoperitonium which normalized in the seventh postoperative day.