Study of Antioxidant, Anti-inflammatory, and DNA-Damage Protection Properties of Some Indian Medicinal Plants Reveal their Possible Role in Combating Psoriasis

  • Neha Arora Laboratory of Morphogenesis, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi-221005
  • Deepika Tripathi Laboratory of Morphogenesis, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi-221005
  • Neha Pandey Laboratory of Morphogenesis, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi-221005
  • Krishna Kumar Rai Laboratory of Morphogenesis, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi-221005
  • Sanjay Kumar Rai Horticulture Department, DRCAU, Samastipur, Bihar
  • Shashi Pandey-Rai Laboratory of Morphogenesis, Centre of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi-221005
Keywords: Reactive oxygen species, Psoriasis, Antioxidants, Anti-inflammatory, Oxidative DNA damage

Abstract

Reactive oxygen species (ROS) are generated due to severe oxidative stress, thereby resulting in pathogenesis of various disorders in humans, including psoriasis. DNA damage is the major manifestation of long term ROS exposure. ROS can be scavenged by natural antioxidant compounds present in medicinal plants. In this study, aqueous, methanolic and chloroform extracts of eleven dermatologically significant Indian medicinal plants were evaluated for their ROS scavenging and antioxidant properties, using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, Trolox equivalent antioxidant capacity (TEAC), Ferric reducing antioxidant power assay (FRAP), along with total phenolic content determination. Lipoxygenase inhibition assay was conducted to determine anti-inflammatory activities. DNA-damage protective capacities were also assessed using plasmid pBluescript II SK(–) DNA, where DNA damage was induced by Fenton reaction. The study reveals that the extracts of T. cordifolia, C. paniculatus, C. longa and A. vera performed far much better, in almost all the assays, with regards to P. corylifolia, a medicinal plant traditionally used to treat psoriasis, thus indicating these plants to be potent sources of effective drug formulation for treatment of psoriasis.

Int. J. Appl. Sci. Biotechnol. Vol 5(2): 141-149

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Abstract
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Published
2017-06-29
How to Cite
Arora, N., Tripathi, D., Pandey, N., Rai, K. K., Rai, S. K., & Pandey-Rai, S. (2017). Study of Antioxidant, Anti-inflammatory, and DNA-Damage Protection Properties of Some Indian Medicinal Plants Reveal their Possible Role in Combating Psoriasis. International Journal of Applied Sciences and Biotechnology, 5(2), 141-149. https://doi.org/10.3126/ijasbt.v5i2.17618
Section
Research Articles