Counteracting Congenital Cataract

  • Arthy Narayanan Department of Biotechnology, BMS College Of Engineering, Bangalore
  • B.V. Sai Sinduri Department of Biotechnology, BMS College Of Engineering, Bangalore
  • S Pradeep Department of Biotechnology, BMS College Of Engineering, Bangalore
Keywords: CRYAA, Alpha A Crystallin, Congenital cataract

Abstract

Congenital or hereditary cataract is a condition where the lens of the eye is not completely transparent resulting in cloudy or blocked vision. Many genes have been found to influence the formation of a cataract. The gene that has been focused on in this paper is the CRYAA gene which codes for the crystallin A protein, a major constituent protein of the lens. Mutations and misfoldings of this protein have been seen to be a major cause of congenital cataract. So, we did an analysis of the gene and the protein using computational tools. As a solution to the condition, we computationally devised a vector that carries the correct CRYAA gene. This vector could be used during the pre-natal stage of pregnancy for children who are believed to inherit this condition.

Int. J. Appl. Sci. Biotechnol. Vol 5(2): 216-221

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Published
2017-06-29
How to Cite
Narayanan, A., Sai Sinduri, B., & Pradeep, S. (2017). Counteracting Congenital Cataract. International Journal of Applied Sciences and Biotechnology, 5(2), 216-221. https://doi.org/10.3126/ijasbt.v5i2.17620
Section
Research Articles