Serum Lipoprotein(A) Concentration is a Better Predictor of Myocardial Infarction than Traditional Lipid Profile and Lipid Ratios

H K Tamang, U Timilsina, K P Singh, R Shrestha, K Bist, L Maharjan, S Shakya

Abstract

Background- Lipoprotein(a) is a variant form of Low Density Lipoprotein (LDL) which comprises of an LDL like particle in which apo B-100 is firmly linked to apo-a glycoprotein. A large number of genetic and epidemiologic studies have identified Lipoprotein(a) as a risk factor for atherosclerotic diseases such as coronary heart disease and stroke. Based on our knowledge, this is the first study comparing Lipoprotein(a) with lipid profile and lipid ratios in Nepal.

Aim & Objective- To compare the serum Lipoprotein(a) and Lipid panel concentrations in myocardial infarction patients and normal healthy control subjects.

Materials & Methods- Study was carried out in 45 myocardial infarction patients as cases and 45 healthy subjects as controls. Lipoprotein(a) and Lipid profile tests were measured in serum using HumaStar 600 fully automated analyzer, Human, Germany.

Results- Mean serum Lipoprotein(a) concentration in myocardial infarction group was significantly higher as compared to healthy controls. Lipid panel assays were not statistically significant among the groups.

Conclusion- Our study revealed that myocardial infarction patients have elevated levels of serum Lipoprotein(a) as compared to healthy subjects. High concentration of serum Lipoprotein(a) is strongly associated with the risk of coronary heart disease.

DOI: http://dx.doi.org/10.3126/ijasbt.v1i3.8583

Int J Appl Sci Biotechnol, Vol. 1(3) 2013 : 106-109

Keywords

Lipoprotein(a); low density lipoprotein; myocardial infarction; lipid panel

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DOI: http://dx.doi.org/10.3126/ijasbt.v1i3.8583

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