Assessment of Role of Human Papilloma Virus in Patients with Oral Squamous Cell Carcinoma

Authors

  • Krishan Kumar Tyagi Kathmandu Medical College, Sinamangal, Kathmandu, Nepal
  • Megha Pradhan Kathmandu Medical College, Sinamangal, Kathmandu, Nepal
  • Rajbir Kaur Grewal Desh Bhagat Dental College & Hospital
  • Prabesh Sherchan Kathmandu Medical College, Sinamangal, Kathmandu, Nepal
  • KSA Pasha College of Medical Sciences, Chitwan, Nepal

DOI:

https://doi.org/10.3126/jcmsn.v15i2.22707

Keywords:

Cell carcinoma, human papilloma virus, oral squamous

Abstract

Background: Head and neck malignancies include malignancies instigating in the oral cavity, the orophar-ynx, the hypopharynx and the larynx. We planned the present study to assess the role of human papilloma virus (HPV) in patients with oral squamous cell carcinoma (OSCC).

Methods: The present study included assessment of role of human papilloma virus in patients with oral squamous cell carcinoma. A total of 50 histopathologic proven cases of well differentiated OSCC were included in the present study. A total of 50 healthy oral mucosal tissues (controls) were also included in the present study. The controls were obtained while surgical removing the impacted teeth. DNA was obtained from the tissue sections and underwent Polymerization chain reaction for identification of HPV 16/18. All the results were summarized in Microsoft excel sheet and were analyzed by SPSS software.

Results: HPV was absent in all the cases of control group, whereas among the OSCC group, the HPV was detected in 46 percent of the cases. In the remaining 54 per-cent of the cases of the OSCC group, HPV was absent. Significant results were obtained while comparing the presence of HPV in between the OSCC group and the control group.

Conclusions: HPV was present in sig-nificant number of OSCC cases. Therefore; HPV might play a contributing role in the etio-pathogenesis of OSCC.

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Author Biographies

Krishan Kumar Tyagi, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal

Department of Oral Pathology

Megha Pradhan, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal

Department of Pedodontics

Rajbir Kaur Grewal, Desh Bhagat Dental College & Hospital

Department of Oral Pathology

Prabesh Sherchan, Kathmandu Medical College, Sinamangal, Kathmandu, Nepal

Department of Orthodontics

KSA Pasha, College of Medical Sciences, Chitwan, Nepal

Department of Prosthodontics

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Published

2019-06-30

How to Cite

Tyagi, K. K., Pradhan, M., Grewal, R. K., Sherchan, P., & Pasha, K. (2019). Assessment of Role of Human Papilloma Virus in Patients with Oral Squamous Cell Carcinoma. Journal of College of Medical Sciences-Nepal, 15(2), 125–127. https://doi.org/10.3126/jcmsn.v15i2.22707

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Section

Original Articles