Intracranial Hemorrhage Caused by Vitamin K Deficiency Beyond Neonatal Period

  • Sudhir Adhikari Manipal College of Medical Sciences, Pokhara
  • Eva Gauchan Manipal College of Medical Sciences, Pokhara
  • Tejesh Malla Manipal College of Medical Sciences, Pokhara
  • Brijesh Sathian Manipal College of Medical Sciences, Pokhara
  • Kalipatanam Seshagiri Rao Manipal College of Medical Sciences, Pokhara
Keywords: Intracranial haemorrhage-Late onset haemorrhagic disease of newborn -Vitamin K

Abstract

Vitamin K deficiency bleeding (VKDB) can manifest as intracranial hemorrhage (ICH) and is still prevalent in poor resource countries. Infants aged one to twelve months with the diagnosis of ICH from 1st July 2011 to 30th June 2016 were included. There were 16 cases of ICH attributed to vitamin K deficiency. Clinical presentations were anemia16 (100%), bulged fontanel 13(81.3%), seizures 10(62.5%), vomiting 8(50%) and fever 9(56.3%). Mean INR at admission was 8.575±7.267 and 1.868±0.838 after three doses of vitamin K administration. Sites of intracranial bleed were parenchymal 5(31.3%), subdural 4(25%), extradural 2(12.5%), ventricular 2(12.5%). In 3(18.8%) of cases bleeding was more extensive involving more than one site. Mortality was 4(25%) and 3(18.8%) had abnormal neurological findings at discharge. There is an urgent need for national policy for vitamin K prophylaxis at birth.

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Author Biographies

Sudhir Adhikari, Manipal College of Medical Sciences, Pokhara
Assistant Professor, Department of Pediatrics
Eva Gauchan, Manipal College of Medical Sciences, Pokhara
Associate Professor,
Department of Paediatrics
Tejesh Malla, Manipal College of Medical Sciences, Pokhara
Associate Professor, Department of Paediatrics
Brijesh Sathian, Manipal College of Medical Sciences, Pokhara
Assistant, Department of community medicine
Kalipatanam Seshagiri Rao, Manipal College of Medical Sciences, Pokhara
Professor of Paediatrics
Published
2017-10-04
How to Cite
Adhikari, S., Gauchan, E., Malla, T., Sathian, B., & Rao, K. (2017). Intracranial Hemorrhage Caused by Vitamin K Deficiency Beyond Neonatal Period. Journal of Nepal Paediatric Society, 37(1), 104-107. https://doi.org/10.3126/jnps.v37i1.16301
Section
Case Series