Occurrence of CCR5 Heterozygous 32 bp Deletion in Nepali Ethnic Groups

Authors

  • Nanda Bahadur Singh Unit of Human Biology and Genetics, Department of Biological Sciences, School of Science, University of Tokyo, Tokyo 113-0033, Japan Address to Correspondence: Central Department of Zoology, Tribhuvan University, Kirtipur, Kathmandu

Keywords:

CCR5 gene, 32 bp deletion, HIV-1 infection, genotypes, ethnic groups

Abstract

The Chemokine (C-C) receptor 5 (CCR5) as one of the small signaling proteins, is a HIV-1 resistant gene. The major boosting to the study of CCR5 gene among ethnic groups in the world is the detection of 32 bp deletion in its heterozygous and homozygous condition which is responsible for relative or absolute resistance to HIV-1 infection. A total of 456 samples belonging to six Nepalese ethnic groups were subjected to genotyping by the use of PCR-RFLP for detecting 32 bp deletion on exon 3 of CCR5 gene. Finally, allele frequencies of 32 bp deletion among Nepalese ethnic groups were calculated by the use of Hardy-Weinberg formula for analysis and interpretation. Chidimar ethnic group, for the first time, showed heterozygous 32 bp deletion at the population level in Asia-pacific region is an excitement in which Chidimar might have conferred resistance against HIV-1 infection in Nepal.

Journal of Institute of Science and Technology, 2014, 19(2): 105-108

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Published

2015-11-09

How to Cite

Occurrence of CCR5 Heterozygous 32 bp Deletion in Nepali Ethnic Groups. (2015). Journal of Institute of Science and Technology, 19(2), 105-108. https://doi.org/10.3126/jist.v19i2.13862

Issue

Vol. 19 No. 2 (2014)

Section

Research Articles

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The copyright of the articles is held by the Institute of Science and Technology, Tribhuvan University (IoST- TU). The views and interpretations in this journal are those of the author(s). They are not attributable to the IoST-TU and do not imply the expression of any opinion concerning the legal status of any country, territory, city, area of its authorities, or concerning the delimitation of its frontiers or boundaries. The corresponding author is responsible for any conflict of interest between authors and others.

The articles in the Journal of Institute of Science and Technology are licensed under a Creative Commons Attribution- Share Alike 4.0 International License (CC: BY-NC), which permits use, distribution and reproduction in any medium or format, remix, transfer, and build upon the materials for any purpose, even commercially, provided the original work is properly cited.

How to Cite

Occurrence of CCR5 Heterozygous 32 bp Deletion in Nepali Ethnic Groups. (2015). Journal of Institute of Science and Technology, 19(2), 105-108. https://doi.org/10.3126/jist.v19i2.13862