Thyroid Function and Thyroglobulin Level in Iodine-Deficient Children of Eastern Nepal

Authors

  • Saroj Kunwar Modern Technical College, Lalitpur, Nepal
  • Saroj Khatiwada University of New South Wales Sydney, Australia https://orcid.org/0000-0002-5158-9324
  • Basanta Gelal B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
  • Saroj Thapa B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
  • Gaurishankar Shah B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
  • Nirmal Baral B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal
  • Madhab Lamsal B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

DOI:

https://doi.org/10.3126/njb.v9i1.38670

Keywords:

Children, Iodine deficiency, Nepal, Thyroid dysfunction, Urinary iodine concentration (UIC)

Abstract

Iodine deficiency during childhood affects physical and mental development. Iodine deficiency or excess both can negatively impact thyroid function. We conducted this study to assess iodine nutrition and thyroid function in children with insufficient urinary iodine concentration. A community-based cross-sectional study was conducted among the selected schools of Udayapur district. Urinary iodine concentration (UIC) was measured in 1012 school children (6-14 years). Based on UIC data, 83 blood samples were collected to measure serum thyroglobulin (Tg), thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), and free thyroxine (fT4). UIC was measured by ammonium persulfate digestion method, and Tg, TSH, fT4, and fT3 were measured using ELISA kits. The median UIE was 236 µg/L, and 11.1% of the children had insufficient UIC. The mean fT3, fT4, and TSH in children with insufficient UIC were 2.55±0.43 pg/mL, 0.96±0.28 ng/dL, and 3.60±1.44 mIU/L respectively. Among children with low UIC levels, the median Tg was 17.5 ng/mL. Overt hypothyroidism was seen in 6%, and subclinical hypothyroidism in 3.6%. The children had sufficient iodine nutrition, and the frequency of thyroid dysfunction was low among the children with insufficient UIC.

Downloads

Download data is not yet available.
Abstract
66
PDF
49

Author Biographies

Saroj Kunwar, Modern Technical College, Lalitpur, Nepal

Department of Biochemistry

Saroj Khatiwada, University of New South Wales Sydney, Australia

School of Medical Sciences

Basanta Gelal, B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

Department of Biochemistry

Saroj Thapa, B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

Department of Biochemistry

Gaurishankar Shah, B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

Department of Obstetrics and Gynaecology

Nirmal Baral, B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

Department of Biochemistry

Madhab Lamsal, B P Koirala Institute of Health Sciences, Ghopa, Dharan, Nepal

Department of Biochemistry

Downloads

Published

2021-07-31

How to Cite

Kunwar, S., Khatiwada, S., Gelal, B., Thapa, S., Shah, G., Baral, N., & Lamsal, M. (2021). Thyroid Function and Thyroglobulin Level in Iodine-Deficient Children of Eastern Nepal. Nepal Journal of Biotechnology, 9(1), 75–78. https://doi.org/10.3126/njb.v9i1.38670

Issue

Section

Original Research Articles