Lovastatin production by <i>Aspergillus fischeri</i> under solid state fermentation from coconut oil cake

Authors

  • Parvatham Madhu Latha NRI College of Pharmacy, Pothavarappadu, Agiripalli Mandal, Vijayawada Rural, Andhra Pradesh.
  • Pallem Chanakya Centre for Biotechnology, Department of Chemical Engineering, AU College of Engineering (A), Andhra University, Visakhapatnam, Andhra Pradesh.
  • Manipati Srikanth NRI Academy of Medical Sciences, China Kakani, Mangalagiri Mandal, Guntur, Andhra Pradesh

DOI:

https://doi.org/10.3126/njb.v2i1.5641

Keywords:

Lovastatin, Aspergillus fischeri, Coconut oil cake, Fermentation parameters, Optimization

Abstract

The main aim of the present investigation was to optimize the fermentation parameters that enhance the maximum production of lovastatin by Aspergillus fischeri using coconut oil cake as the solid substrate under solid state fermentation. The maximum yield of lovastatin (14.77 mg/g dry substrate) using coconut oil cake as the substrate was achieved with the following optimized process parameters: fermentation time (7 days), initial moisture content (60% v/w), inoculum volume (2ml of five day old culture), initial pH (5.0), incubation temperature (30ºC), lactose (1% w/v) and malt extract (1% w/v).

Keywords: Lovastatin; Aspergillus fischeri; Coconut oil cake; Fermentation parameters; Optimization

DOI: http://dx.doi.org/10.3126/njb.v2i1.5641

Nepal Journal of Biotechnology Jan.2012, Vol.2(1): 26-36

 

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How to Cite

Latha, P. M., Chanakya, P., & Srikanth, M. (2012). Lovastatin production by <i>Aspergillus fischeri</i> under solid state fermentation from coconut oil cake. Nepal Journal of Biotechnology, 2(1), 26–36. https://doi.org/10.3126/njb.v2i1.5641

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Original Research Articles